Journal ArticleDOI
Apoptosis in irradiated murine tumors.
TLDR
Factors other than mitotic activity may influence tumor radiosensitivity, and one of these may be susceptibility to induction of apoptosis (programmed cell death), because this was a prominent early radiation response by the radiosensitive OCaI tumors.Abstract:
Early radiation responses of transplantable murine ovarian (OCaI) and hepatocellular (HCaI) carcinomas were examined at 6, 24, 48, 96, and 144 h after single photon doses of 25, 35, or 45 Gy. Previous studies using tumor growth delay and tumor radiocurability assays had shown OCaI tumors to be relatively radiosensitive and HCaI tumors to be radioresistant. At 6 h, approximately 20% of nuclei in OCaI tumors showed aberrations characteristic of cell death by apoptosis. This contrasted to an incidence of 3% in HCaI tumors. Mitotic activity was eliminated in OCaI tumors but was only transiently suppressed in HCaI tumors. At 24-96 h, OCaI tumors continued to display apoptosis and progressive necrosis, whereas HCaI tumors responded by exhibiting marked pleomorphism. Factors other than mitotic activity may influence tumor radiosensitivity, and one of these may be susceptibility to induction of apoptosis (programmed cell death), because this was a prominent early radiation response by the radiosensitive OCaI tumors.read more
Citations
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Journal ArticleDOI
Apoptosis. Its significance in cancer and cancer Therapy
TL;DR: C‐myc expression has been shown to be involved in the initiation of apoptosis in some situations, and bcl‐2 has emerged as a new type of proto‐oncogene that inhibits apoptosis, rather than stimulating mitosis.
Journal Article
bcl-2 and p53 Oncoprotein Expression during Colorectal Tumorigenesis
TL;DR: Abnormal activation of the bcl-2 gene appears to be an early event in colorectal tumorigenesis that can inhibit apoptosis in vivo and may facilitate tumor progression.
Journal Article
In vivo enhancement of tumor radioresponse by C225 antiepidermal growth factor receptor antibody.
Luka Milas,Kathy A. Mason,Nancy Hunter,Sven Petersen,Michitaka Yamakawa,Kian K. Ang,John Mendelsohn,Zhen Fan +7 more
TL;DR: It is concluded that C225 anti-EGFR antibody enhances tumor radioresponse by multiple mechanisms that may involve direct and indirect actions on tumor cell survival.
Journal Article
Basic Fibroblast Growth Factor Protects Endothelial Cells against Radiation-induced Programmed Cell Death in Vitro and in Vivo
Zvi Fuks,Roger S. Persaud,Alan A. Alfieri,Maureen McLoughlin,Desiree Ehleiter,Jeffery L. Schwartz,Andrew P. Seddon,Carlos Cordon-Cardo,Adriana Haimovitz-Friedman +8 more
TL;DR: The findings suggest that interphase apoptosis may represent a biologically relevant mechanism of radiation-induced cell kill in nonlymphoid mammalian cells both in vitro and in vivo and that natural protection mechanisms against this effect may be associated with the level of radiation resistance in normal and malignant tissues in vivo.
Journal Article
Inverse Relationship between Epidermal Growth Factor Receptor Expression and Radiocurability of Murine Carcinomas
TL;DR: The pretreatment assessment of EGFR expression could predict radiotherapy outcome and may assist in selecting an effective treatment modality.
References
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Journal ArticleDOI
Apoptosis: a basic biological phenomenon with wide-ranging implications in tissue kinetics.
TL;DR: Apoptosis seems to be involved in cell turnover in many healthy adult tissues and is responsible for focal elimination of cells during normal embryonic development, and participates in at least some types of therapeutically induced tumour regression.
Book ChapterDOI
Cell death : the significance of apoptosis
TL;DR: It has proved feasible to categorize most if not all dying cells into one or the other of two discrete and distinctive patterns of morphological change, which have, generally, been found to occur under disparate but individually characteristic circumstances.
Journal ArticleDOI
Apoptosis. The role of the endonuclease
TL;DR: In apoptosis, selective activation of an endogenous endonuclease appears to be responsible not only for widespread chromatin cleavage but also for the major nuclear morphologic changes, including conservation of the nucleolin-rich fibrillar center.