R
R. G. Morris
Researcher at University of Edinburgh
Publications - 13
Citations - 4940
R. G. Morris is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Apoptosis & Cyclin D1. The author has an hindex of 12, co-authored 13 publications receiving 4904 citations.
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Journal ArticleDOI
Thymocyte apoptosis induced by p53-dependent and independent pathways
Alan Richard Clarke,Colin A. Purdie,Colin A. Purdie,David J. Harrison,R. G. Morris,Colin C. Bird,Martin L. Hooper,Andrew H. Wyllie +7 more
TL;DR: The results show that p53 exerts a significant and dose-dependent effect in the initiation of apoptosis, but only when it is induced by agents that cause DNA-strand breakage.
Journal ArticleDOI
Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis.
TL;DR: The data confirm that the condensed chromatin which characterizes apoptosis morphologically consists of endogenously digested chromatin fragments, and provide support for the view that at least some cells enter apoptosis by a process dependent upon macromolecular synthesis.
Journal Article
Microsatellite instability and the role of hMSH2 in sporadic colorectalcancer.
Vivien J. Bubb,L J Curtis,Chris Cunningham,Malcolm G. Dunlop,Andrew D. Carothers,R. G. Morris,Susan White,Colin C. Bird,Andrew H. Wyllie +8 more
TL;DR: A systematic analysis of mismatch repair deficiency in 215 Scottish patients with sporadic colorectal tumours found that 16.4% of tumours exhibited MSI; survival analysis by Cox proportional hazards method showed a substantial survival advantage for patients with tumours showing MSI, independent of other prognostic factors.
Journal ArticleDOI
Normal spatial learning despite regional inhibition of LTP in mice lacking Thy-1
M. Nosten-Bertrand,M.L. Errington,Kerry P.S.J. Murphy,Y Tokugawa,E Barboni,E Barboni,Elena N. Kozlova,D Michalovich,R. G. Morris,Jack Silver,Colin L. Stewart,Timothy V. P. Bliss,Roger J. Morris,Roger J. Morris +13 more
TL;DR: In mice in which the gene encoding Thy-1 has been inactivated, there is a regionally selective impairment of LTP in vivo in the hippocampal formation: LTP is normal in area CA1 but strongly inhibited in the dentate gyrus.
Journal Article
High frequency of APC loss in sporadic colorectal carcinoma due to breaks clustered in 5q21-22.
Ashton-Rickardt Pg,Malcolm G. Dunlop,Yusuke Nakamura,R. G. Morris,Colin A. Purdie,C. M. Steel,H.J. Evans,Colin C. Bird,Andrew H. Wyllie +8 more
TL;DR: Using DNA probes homologous to polymorphic sequences flanking and close to the APC locus it is shown that more than half of a large series of carcinomas had lost at least one flanking allele, implying that APC loss is an early event in colorectal carcinogenesis.