Journal ArticleDOI
Arthroscopic Microscopy of Articular Cartilage Using Optical Coherence Tomography
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TLDR
Whether optical coherence tomography images of human cartilage can be acquired arthroscopically and whether the resulting images have high correlation with histopathology is investigated.Abstract:Â
BackgroundOptical coherence tomography is an echograph of infrared light that can yield microscopic cross-sectional images of articular cartilage without removing or damaging the tissue.HypothesisTo determine whether optical coherence tomography images of human cartilage can be acquired arthroscopically and whether the resulting images have high correlation with histopathology.MethodsOptical coherence tomography was configured into an arthroscope and used to image 2 human cadaver knees and 45 cores harvested from 9 osteoarthritic knees. The imaged cartilage was then processed for histological analysis. Optical coherence tomography images and histology were graded using a modified Mankin structural score. Agreement was determined using weighted kappa statistics. Morphometric analysis performed on optical coherence tomography images was correlated with histomorphometric analysis using linear regression.ResultsImaging of the medial and lateral femoral condyles and trochlea was readily accomplished using the ...read more
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Diagnosis of osteoarthritis: Imaging
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In vitro exposure to 0.5% bupivacaine is cytotoxic to bovine articular chondrocytes.
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References
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Journal ArticleDOI
Optical coherence tomography
David Huang,Eric A. Swanson,Charles P. Lin,Joel S. Schuman,William G. Stinson,Warren Chang,Michael R. Hee,Thomas J. Flotte,Kenton W. Gregory,Carmen A. Puliafito,James G. Fujimoto +10 more
TL;DR: OCT as discussed by the authors uses low-coherence interferometry to produce a two-dimensional image of optical scattering from internal tissue microstructures in a way analogous to ultrasonic pulse-echo imaging.
Journal ArticleDOI
Treatment of deep cartilage defects in the knee with autologous chondrocyte transplantation
TL;DR: Cultured autologous chondrocytes can be used to repair deep cartilage defects in the femorotibial articular surface of the knee joint.
Journal ArticleDOI
Estimates of the prevalence of arthritis and selected musculoskeletal disorders in the United States
Reva C. Lawrence,Charles G. Helmick,Frank C. Arnett,Richard A. Deyo,David T. Felson,Edward H. Giannini,Stephen P. Heyse,Rosemarie Hirsch,Marc C. Hochberg,Gene G. Hunder,Matthew H. Liang,Stanley R. Pillemer,Virginia D. Steen,Frederick Wolfe +13 more
TL;DR: Given the limitations of the data on which they are based, this report provides the best available prevalence estimates for arthritis and other rheumatic conditions overall, and for selected musculoskeletal disorders, in the US population.
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The etiology of chondromalacia patellae
TL;DR: Rubbing of the medial patellar facet on the rim at the upper border of the lateral femoral condyle can explain in part the etiology of chondromalacia.
Journal ArticleDOI
Biochemical and metabolic abnormalities in articular cartilage from osteo-arthritic human hips. II. Correlation of morphology with biochemical and metabolic data.
TL;DR: For thirty-two areas of cartilage from nine osteo-arthritic and four "normal" femoral heads a histologic-histochemical grade was assigned as an index of severity of the osteo -arthritic process.