Association between maternal serum 25-hydroxyvitamin D level and pregnancy and neonatal outcomes: systematic review and meta-analysis of observational studies
Fariba Aghajafari,Tharsiya Nagulesapillai,Paul E. Ronksley,Suzanne Tough,Maeve O'Beirne,Doreen M. Rabi +5 more
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TLDR
Vitamin D insufficiency is associated with an increased risk of gestational diabetes, pre-eclampsia, and small for gestational age infants.Abstract:
Objective To assess the effect of 25-hydroxyvitamin D (25-OHD) levels on pregnancy outcomes and birth variables. Design Systematic review and meta-analysis. Data sources Medline (1966 to August 2012), PubMed (2008 to August 2012), Embase (1980 to August 2012), CINAHL (1981 to August 2012), the Cochrane database of systematic reviews, and the Cochrane database of registered clinical trials. Study selection Studies reporting on the association between serum 25-OHD levels during pregnancy and the outcomes of interest (pre-eclampsia, gestational diabetes, bacterial vaginosis, caesarean section, small for gestational age infants, birth weight, birth length, and head circumference). Data extraction Two authors independently extracted data from original research articles, including key indicators of study quality. We pooled the most adjusted odds ratios and weighted mean differences. Associations were tested in subgroups representing different patient characteristics and study quality. Results 3357 studies were identified and reviewed for eligibility. 31 eligible studies were included in the final analysis. Insufficient serum levels of 25-OHD were associated with gestational diabetes (pooled odds ratio 1.49, 95% confidence interval 1.18 to 1.89), pre-eclampsia (1.79, 1.25 to 2.58), and small for gestational age infants (1.85, 1.52 to 2.26). Pregnant women with low serum 25-OHD levels had an increased risk of bacterial vaginosis and low birthweight infants but not delivery by caesarean section. Conclusion Vitamin D insufficiency is associated with an increased risk of gestational diabetes, pre-eclampsia, and small for gestational age infants. Pregnant women with low 25-OHD levels had an increased risk of bacterial vaginosis and lower birth weight infants, but not delivery by caesarean section.read more
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Vitamin D deficiency.
TL;DR: It is suggested that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units, outpatients, and referrals to social services, but for house doctors to assess overdoses would provide no economy for the psychiatric or social services.
Journal ArticleDOI
Vitamin D and multiple health outcomes: umbrella review of systematic reviews and meta-analyses of observational studies and randomised trials
TL;DR: Evidence does not support the argument that vitamin D only supplementation increases bone mineral density or reduces the risk of fractures or falls in older people, and highly convincing evidence of a clear role of vitamin D does not exist for any outcome, but associations with a selection of outcomes are probable.
Journal ArticleDOI
Vitamin D supplementation for women during pregnancy
TL;DR: In this paper, the effect of supplementing with vitamin D alone or in combination with calcium or other vitamins and minerals given to women during pregnancy can safely improve maternal and neonatal outcomes.
Journal ArticleDOI
Vitamin D supplementation in pregnancy: a systematic review.
Nicholas C. Harvey,Christopher Holroyd,Georgia Ntani,Kassim Javaid,Philip Cooper,Rebecca J Moon,Zoe Cole,Tannaze Tinati,Keith M. Godfrey,Elaine M. Dennison,Nick Bishop,Janis Baird,Cyrus Cooper +12 more
TL;DR: The evidence base is currently insufficient to support definite clinical recommendations regarding vitamin D supplementation in pregnancy, and modest positive relationships were identified between maternal 25(OH)D status and offspring birthweight, bone mass and serum calcium concentrations.
Journal ArticleDOI
Global prevalence and disease burden of vitamin D deficiency: a roadmap for action in low- and middle-income countries.
Daniel E Roth,Steven A. Abrams,John F. Aloia,Gilles Bergeron,Megan W. Bourassa,Kenneth H. Brown,Mona S. Calvo,Kevin D. Cashman,Gerald F Combs,Luz Maria De-Regil,Maria Elena Jefferds,Kerry S Jones,Hallie Kapner,Adrian R. Martineau,Lynnette M. Neufeld,Rosemary L. Schleicher,Tom D. Thacher,Susan J. Whiting +17 more
TL;DR: If a high prevalence of vitamin D deficiency is identified or the risk for vitamin D deficiencies is determined to be high based on proxy indicators, food fortification and/or targeted vitamin D supplementation policies can be implemented to reduce the burden ofitamin D deficiency–related conditions in vulnerable populations.
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Vitamin D deficiency.
TL;DR: It is suggested that if assessment of overdoses were left to house doctors there would be an increase in admissions to psychiatric units, outpatients, and referrals to social services, but for house doctors to assess overdoses would provide no economy for the psychiatric or social services.