Journal ArticleDOI
Autoimmune chronic active hepatitis masquerading as acute hepatitis.
TLDR
As immunosup-pressive therapy is a beneficial treatment of autoimmune chronic active hepatitis, an acute presentation of this liver disease should be considered as an alternative diagnosis to acute non-A, non-B hepatitis in patients with these clinical characteristics.Abstract:
An unusual clinical presentation of chronic active hepatitis is the abrupt onset of symptoms and jaundice, suggesting acute viral hepatitis. In this report, six patients had the acute onset of a severe liver disease. Five of the patients were female and ranged in age from 13 to 64 years. Marked elevations in the total bilirubin (17.1 +/- 11.4 mg/dl), AST (1,346 +/- 352 mIU/ml), and ALT (1,043 +/- 213 mIU/ml) were present (mean +/- SD). Negative serologies for hepatitis A and B were found. Liver histology showed severe hepatocellular injury. A diagnosis of autoimmune chronic active hepatitis with acute features was made on the basis of high titers of antinuclear antibody and smooth muscle antibody and the presence of hypergammaglobulinemia. As immunosuppressive therapy is a beneficial treatment of autoimmune chronic active hepatitis, an acute presentation of this liver disease should be considered as an alternative diagnosis to acute non-A, non-B hepatitis in patients with these clinical characteristics.read more
Citations
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Journal ArticleDOI
Diagnosis and management of autoimmune hepatitis.
Michael P. Manns,Albert J. Czaja,James D. Gorham,Edward L. Krawitt,Giorgina Mieli-Vergani,Diego Vergani,John M. Vierling +6 more
TL;DR: These guidelines on autoimmune hepatitis provide a data-supported approach to the diagnosis and management of this disease.
Journal ArticleDOI
Diagnosis and treatment of autoimmune hepatitis
TL;DR: These guidelines provide a data-supported approach to the diagnosis and management of patients with autoimmune hepatitis and modified the categories of the Infectious Diseases Society of America’s Quality Standards to standardize recommendations.
Journal ArticleDOI
Diagnosis and management of autoimmune hepatitis.
TL;DR: Autoimmune hepatitis is characterized by increased serum aminotransferase levels, autoantibodies, hypergammaglobulinemia, and interface hepatitis, and presentation can be acute, severe, asymptomatic, or chronic.
Journal ArticleDOI
Usefulness of corticosteroids for the treatment of severe and fulminant forms of autoimmune hepatitis.
Philippe Ichai,Jean-Charles Duclos-Vallée,Catherine Guettier,Sonia Ben Hamida,Theresa Antonini,Valérie Delvart,Faouzi Saliba,Daniel Azoulay,Denis Castaing,Didier Samuel +9 more
TL;DR: In conclusion, corticosteroid therapy is of little benefit in severe and fulminant forms of AIH; it may favor septic complications and should not delay LT.
Journal ArticleDOI
The nature and prognostic implications of autoimmune hepatitis with an acute presentation
TL;DR: It is concluded that autoimmune hepatitis with an acute presentation is indistinguishable by clinical and laboratory features from that with a chronic presentation and it is probably a pre-existent subclinical disease that is unmasked by disease progression or an abrupt exacerbation.
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