Patent
Benzopyran derivatives and their use as anti-hypertensives
TLDR
In this article, the derivatives of the benzopyran derivatives of formula (I) wherein the substituents are as defined herein are provided, and the compounds possess vasodilating activity and are useful in the treatment of hypertension.Abstract:
Benzopyran derivatives of formula (I) wherein the substituents are as defined herein are provided. The compounds possess vasodilating activity and are useful in the treatment of hypertension. Pharmaceutical compositions and methods of treating hypertension are also provided.read more
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Aryl urea and related compounds
TL;DR: In this article, the authors defined a set of compounds having the formula "STR1##" and pharmaceutically acceptable salts thereof, where X is a single bond, O, CO, S, NH or N(lower alkyl); Y is O, S or NCN; and R1 to R5' are as defined herein.
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TL;DR: In this paper, the authors define a class of compounds having the formula "STR1## and pharmaceutically acceptable salts thereof" where X is alkyl, Y is a single bond.
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Patrick Betschmann,William A. Carroll,Anna M. Ericsson,Shannon R Fix-Stenzel,Michael Friedman,Gavin C. Hirst,Nathan S. Josephsohn,Biqin Li,Arturo Perez-Medrano,Morytko Michael J,Paul Rafferty,Haipeng Chen +11 more
TL;DR: In this article, the substituents of Formula (I) are defined as useful as therapeutic agents, which are useful as pharmaceutical agents, such as prodrugs thereof, metabolites thereof, isomers thereof, enantiomers thereof and enantiomer thereof.
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Novel benzopyran derivatives, processes for their preparation and their use and preparations containing the compounds
TL;DR: In this paper, the derivatives of the general formula I ##STR1## wherein the substituents are as defined herein are provided, and they show vasodilating and vascular spasmolytic activity and are useful in treating hypertension.
References
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Patent
Pharmaceutically active benzopyran compounds
TL;DR: In this article, the amino moiety was substituted by one or two alkyl groups, or alkylsulphinylamino or alkoxysulphinelamino.
Patent
Anti-hypertensive chromanol derivatives
TL;DR: The NR4 R5 and OR3 moieties are trans having antihypertensive activity, pharmaceutical compositions containing them and processes for their preparation as discussed by the authors, and the NR4 OR3 is trans containing them.
Patent
Anti-hypertensive chromans and chromenes
John M. Evans,Frederick Cassidy +1 more
TL;DR: In this paper, the amino moiety was substituted by one or more groups or atoms selected from the class of C 1-6 alkyl, C 2-7 alkanoyl.
Patent
Pharmaceutically active aminobenzopyrans
TL;DR: In this paper, the class of compounds with anti-hypertensive activity is defined, where the amino moiety can be substituted by one or more than two C 1-6 alkyl groups.
Patent
Chromans and chromenes, compositions and hypertensive method
John M. Evans,Valerie A. Ashwood +1 more
TL;DR: A pharmaceutically acceptable salt or solvate thereof having anti-hypertensive activity, a process for their preparation and their use as pharmaceuticals is described in this article.