Broad-spectrum screening of psychotherapeutic drugs: thiothixene as an antipsychotic and antidepressant.

TLDR: Thiothixene was studied simultaneously in both schizophrenic and depressed patients and was highly efficacious in both types of patients, the degree of improvement for each general group of patients being among the highest of the authors' series of evaluations of antipsychotic and antidepressant drugs.

Abstract: Thiothixene was studied simultaneously in both schizophrenic and depressed patients. Seventy‐two newly admitted schizophrenic patients and 64 depressed patients were treated for 4 weeks with relatively modest doses. As indicated by interview ratings coded on 2 psychiatric rating scales, the drug was highly efficacious in both types of patients, the degree of improvement for each general group of patients being among the highest of our series of evaluations of antipsychotic and antidepressant drugs. When the results of treatment of 5 different schizophrenic Stlbtypes were reviewed, there were no differences between the responses of various types of schizophrenic reactions. The same situation applied to 3 subtypes of depressive reactions. Side effects were chiefly related to weight gain, extrapyramidal syndromes (including akathisia), anticholinergic effects, and sedation.