Cancer potential in liver, lung, bladder and kidney due to ingested inorganic arsenic in drinking water.
TLDR
A significant dose-response relationship was observed between arsenic level in drinking water and mortality of the cancers, and the multiplicity of inorganic arsenic-induced carcinogenicity without showing any organotropism deserves further investigation.Abstract:
In order to compare risk of various internal organ cancers induced by ingested inorganic arsenic and to assess the differences in risk between males and females, cancer potency indices were calculated using mortality rates among residents in an endemic area of chronic arsenicism on the southwest coast of Taiwan, and the Armitage-Doll multistage model. Based on a total of 898,806 person-years as well as 202 liver cancer, 304 lung cancer, 202 bladder cancer and 64 kidney cancer deaths, a significant dose-response relationship was observed between arsenic level in drinking water and mortality of the cancers. The potency index of developing cancer of the liver, lung, bladder and kidney due to an intake of 10 micrograms kg day of arsenic was estimated as 4.3 x 10(-3), 1.2 x 10(-2), 1.2 x 10(-2), and 4.2 x 10(-3), respectively, for males; as well as 3.6 x 10(-3), 1.3 x 10(-2), 1.7 x 10(-2), and 4.8 x 10(-3), respectively, for females in the study area. The multiplicity of inorganic arsenic-induced carcinogenicity without showing any organotropism deserves further investigation.read more
Citations
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Contamination of drinking-water by arsenic in Bangladesh: a public health emergency
TL;DR: The experience in Bangladesh shows that groundwater sources throughout the world that are used for drinking-water should be tested for arsenic, and the fundamental intervention is the identification and provision of arsenic-free drinking water.
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Cancer risks from arsenic in drinking water.
Allan H. Smith,Claudia Hopenhayn-Rich,Michael N. Bates,Helen M. Goeden,Irva Hertz-Picciotto,Heather M. Duggan,Rose Wood,Michael J. Kosnett,Martyn T. Smith +8 more
TL;DR: The evidence assessed here indicates that arsenic can also cause liver, lung, kidney, and bladder cancer and that the population cancer risks due to arsenic in U.S. water supplies may be comparable to those from environmental tobacco smoke and radon in homes.
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Epidemiology and risk factors for kidney cancer
TL;DR: Accumulating evidence suggests an etiologic role in RCC for physical activity, alcohol consumption, occupational exposure to trichloroethylene, and high parity among women, but further research is needed into the potential causal effects of these factors.
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The Broad Scope of Health Effects from Chronic Arsenic Exposure: Update on a Worldwide Public Health Problem
Marisa F. Naujokas,Beth Anderson,Habibul Ahsan,H. Vasken Aposhian,Joseph H. Graziano,Claudia Thompson,William A. Suk +6 more
TL;DR: Testing foods and drinking water for arsenic, including individual private wells, should be a top priority to reduce exposure, particularly for pregnant women and children, given the potential for life-long effects of developmental exposure.
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The second World Cancer Research Fund/American Institute for Cancer Research expert report. Food, nutrition, physical activity, and the prevention of cancer: a global perspective.
TL;DR: In this paper, the causal associations between food, nutrition and physical activity and risk of development of seventeen cancers, as well as of weight gain and obesity, were investigated using a newly developed method with a protocol for standardising the literature search and for analysis and display of the evidence.
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