Journal ArticleDOI
Cardiovascular effects and fatalities associated with intravenous administration of doxycycline to horses and ponies.
J L Riond,Jim E. Riviere,Wendy M. Duckett,Clarke E. Atkins,A. D. Jernigan,Yasuko Rikihisa,S. L. Spurlock +6 more
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TLDR
Results of the present study suggest that the intravenous use of doxycycline should be avoided in horses.Abstract:
Summary
Intravenous use of doxycycline in horses is associated with deleterious side effects on the cardiovascular system which may result in fatalities. At dosages and infusion rates used in these studies, supraventricular tachycardia, systemic arterial hypertension, clinical signs of discomfort, collapse and death were observed. Results of the present study suggest that the intravenous use of doxycycline should be avoided in horses.read more
Citations
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Pharmacokinetics and tissue distribution of doxycycline after oral administration of single and multiple doses in horses
TL;DR: Results suggest that doxycycline administered at a dosage of 20 mg/kg, PO, every 24 hours will result in drug concentrations adequate for killing intracellular bacteria and bacteria with minimum inhibitory concentration < or = 0.25 microg/mL.
Journal ArticleDOI
Study of intragastric administration of doxycycline: pharmacokinetics including body fluid, endometrial and minimum inhibitory concentrations
TL;DR: Based on drug concentrations achieved in the serum, synovial and peritoneal fluids and endometrial tissues and MIC values determined, doxycycline at a dose of 10 mg/kg bwt per os every 12 h may be appropriate for the treatment of infections caused by susceptible (MIC < 0.25 microg/ml) gram-positive organisms in horses.
Journal ArticleDOI
Antibiotic treatment of experimentally Borrelia burgdorferi-infected ponies
Yung-Fu Chang,Yu-We Ku,Chao-Fu Chang,Ching Dong Chang,Sean P. McDonough,Thomas J. Divers,Margaret Pough,Alfonso Torres +7 more
TL;DR: Doxycyline and ceftiofur treatment were inconsistent in eliminating persistent infection in this experimental model, however, tetracycline treatment seems to eliminate persistent infection.
Journal ArticleDOI
Pharmacokinetics of oral doxycycline and concentrations in body fluids and bronchoalveolar cells of foals
TL;DR: Oral administration at a dosage of 10 mg/kg every 12 h would maintain serum, PELF, and BAL cell activity above the minimum inhibitory concentrations of Rhodococcus equi, beta-hemolytic streptococci, and other susceptible bacterial pathogens for the entire dosing interval.
Journal ArticleDOI
Ocular penetration of oral doxycycline in the horse
Margi A. Gilmour,Cyril R. Clarke,Charles G. MacAllister,Jacqueline M. Dedeo,David L. Caudell,Rebecca J. Morton,Martin Pugh +6 more
TL;DR: Repeated oral administration of doxycycline in the horse resulted in steady state serum concentrations of < 1 microg/mL; however, it did not result in appreciable concentrations of drug in the aqueous and vitreous in normal eyes.
References
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Journal Article
Pharmacotherapeutics of the newer tetracyclines.
TL;DR: The superiority of doxycycline and minocycline in their distribution to areas of he body such as the eye, brain, cerebrospinal fluid, and prostate gland suggests that trials of their efficacy in tetracycline-sensitive infections of these areas are indicated.
Journal Article
Pharmacology and toxicology of doxycycline.
J L Riond,Jim E. Riviere +1 more
TL;DR: The pharmacology, toxicology and therapeutics of doxycycline in laboratory animals and man indicate that this drug may be a valuable antimicrobial for use in veterinary medicine.
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Metal complexation of the tetracycline hydrochlorides.
Journal ArticleDOI
Pharmacokinetics, plasma protein binding and dosage of oxytetracycline in cattle and horses.
TL;DR: It is concluded that the currently recommended doses of OT for horses and cows could well underestimate the amount of OT necessary for the successful treatment of infections due to bacteria of average or low sensitivity.