Causes of venous ulceration: a new hypothesis
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TLDR
A new hypothesis linking these two findings proposes that the trapped while cells occlude the capillaries and result in ischaemia of the skin of the leg.Abstract:
Previous hypotheses about the causes of venous ulceration are inconsistent with recently published data. In patients with chronic venous insufficiency the number of functioning capillary loops visible in the skin on microscopy fell after the legs had been dependent for 30 minutes. Another study had shown that leucocytes became trapped in the circulation in dependent legs. A new hypothesis linking these two findings proposes that the trapped while cells occlude the capillaries and result in ischaemia of the skin of the leg.read more
Citations
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Journal ArticleDOI
Investigation of Chronic Venous Insufficiency A Consensus Statement
TL;DR: The most frequent causes of CVI are primary abnormalities of the venous wall and the valves and secondary changes due to previous venous thrombosis that can lead to reflux, obstruction, or both as discussed by the authors.
Journal ArticleDOI
An unrestrained proinflammatory M1 macrophage population induced by iron impairs wound healing in humans and mice
Anca Sindrilaru,Thorsten Peters,Stefan Wieschalka,Corina Baican,Adrian Baican,Henriette Peter,Adelheid Hainzl,Susanne Schatz,Yu Qi,Andrea Schlecht,Johannes M. Weiss,Meinhard Wlaschek,Cord Sunderkötter,Karin Scharffetter-Kochanek +13 more
TL;DR: It is shown that iron overloading of macrophages--as was found to occur in human chronic venous leg ulcers and the mouse model--induced a macrophage population in situ with an unrestrained proinflammatory M1 activation state, which perpetuated inflammation and induced a p16(INK4a)-dependent senescence program in resident fibroblasts, eventually leading to impaired wound healing.
Journal ArticleDOI
Differences in cellular infiltrate and extracellular matrix of chronic diabetic and venous ulcers versus acute wounds
TL;DR: Data indicate that important differences exist in the cellular infiltrate and ECM expression patterns of acute, healing versus chronic wounds, which may be related to the nonhealing status of chronic wounds.
Journal ArticleDOI
Management of venous leg ulcers: clinical practice guidelines of the Society for Vascular Surgery ® and the American Venous Forum.
Thomas F. O'Donnell,Marc A. Passman,William A. Marston,William J. Ennis,Michael C. Dalsing,Robert L. Kistner,Fedor Lurie,Peter K. Henke,Monika L. Gloviczki,Bo Eklof,Julianne Stoughton,Sesadri Raju,Cynthia K. Shortell,Joseph D. Raffetto,Hugo Partsch,Lori C. Pounds,Mary E. Cummings,David L. Gillespie,Robert B. McLafferty,Mohammad Hassan Murad,Thomas W. Wakefield,Peter Gloviczki +21 more
TL;DR: Thomas F. O'Donnell, MD, Marc A. Passman and Peter K. Gloviczki as mentioned in this paper, MD, PhD, Bo G. Eklof et al.
Journal ArticleDOI
Chronic venous insufficiency and venous leg ulceration
TL;DR: The most common form of leg ulcers, venous disease, are the most common forms of lower extremity ulcers as discussed by the authors, and they have a significant impact on quality of life and productivity.
References
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