Journal ArticleDOI
Central nervous system involvement in breast cancer patients: Is the therapeutic landscape changing too slowly?
Caterina Fontanella,Elisa De Carlo,Marika Cinausero,Giacomo Pelizzari,Ilaria Venuti,Fabio Puglisi +5 more
TLDR
In patients with multiple brain metastases who experience important neurological symptoms, palliative treatment, with or without whole brain radiation therapy (WBRT), needs to be considered the first step of a multidisciplinary therapeutic approach.About:
This article is published in Cancer Treatment Reviews.The article was published on 2016-05-01. It has received 23 citations till now. The article focuses on the topics: Metastatic breast cancer & Breast cancer.read more
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Targeted therapeutic options and future perspectives for HER2-positive breast cancer.
Jiani Wang,Binghe Xu +1 more
TL;DR: This review summarizes the most significant and updated research on clinical scenarios related to HER2-positive breast cancer management in order to revise the guidelines of everyday clinical practices.
Journal ArticleDOI
The efficacy of lapatinib and capecitabine in HER-2 positive breast cancer with brain metastases: A systematic review and pooled analysis
Fausto Petrelli,Michele Ghidini,Veronica Lonati,Gianluca Tomasello,Karen Borgonovo,Mara Ghilardi,Mary Cabiddu,Sandro Barni +7 more
TL;DR: Due to its activity on BMs, the L + C combination may be considered for HER-2+ BC that has progressed in the brain, when local therapy has been performed or failed and re-irradiation is not feasible.
Journal ArticleDOI
Current challenges in the management of breast cancer brain metastases.
TL;DR: Challenges in the management of BCBM are reviewed, and potential treatment strategies, including novel agents such as poly-adenosine diphosphate (ADP) ribose polymerase (PARP) inhibitors (olaparib, veliparib), cyclin-dependent kinase 4/6 (CDK4/6) inhibitor (palbociclib, abemaciclib), and taxane derivatives are reviewed.
Journal ArticleDOI
Efficacy of T-DM1 for leptomeningeal and brain metastases in a HER2 positive metastatic breast cancer patient: new directions for systemic therapy - a case report and literature review
Giuseppina Rosaria Rita Ricciardi,Alessandro Russo,Tindara Franchina,Silvia Schifano,Giampiero Mastroeni,Anna Santacaterina,Vincenzo Adamo +6 more
TL;DR: This is the first case reporting interesting antitumor activity of T-DM1 and concomitant WBRT in both brain and leptomeningeal metastases, with a favorable safety profile and prolonged extracranial disease control.
Journal ArticleDOI
Antiproliferative activities of the second-generation antipsychotic drug sertindole against breast cancers with a potential application for treatment of breast-to-brain metastases
Wei Zhang,Cunlong Zhang,Feng Liu,Yu Mao,Wei Xu,Tingting Fan,Qinsheng Sun,He Shengnan,Yu Zong Chen,Wei Guo,Ying Tan,Yuyang Jiang +11 more
TL;DR: It is discovered that sertindole showed broad antiproliferative activities against seven cancer types including 29 cell-lines and exhibited potent effects toward breast cancer cell- lines, with half maximal concentration to inhibit proliferation by 50% (IC50) as low as 800 nM.
References
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Cancer statistics, 2016
TL;DR: Overall cancer incidence trends are stable in women, but declining by 3.1% per year in men, much of which is because of recent rapid declines in prostate cancer diagnoses, and brain cancer has surpassed leukemia as the leading cause of cancer death among children and adolescents.
SEER Cancer Statistics Review, 1975-2003
Lynn A. G. Ries,D. Harkins,Martin Krapcho,Angela B. Mariotto,Barry A. Miller,Eric J. Feuer,Limin X. Clegg,M. P. Eisner,Marie-Josèphe Horner,Nadia Howlader,Matthew J. Hayat,Benjamin F. Hankey,Brenda K. Edwards +12 more
Journal ArticleDOI
A Randomized Trial of Surgery in the Treatment of Single Metastases to the Brain
Roy A. Patchell,Phillip A. Tibbs,John W. Walsh,Robert J. Dempsey,Yosh Maruyama,Richard J. Kryscio,William R. Markesbery,John S. Macdonald,Byron Young +8 more
TL;DR: It is concluded that patients with cancer and a single metastasis to the brain who receive treatment with surgical resection plus radiotherapy live longer, have fewer recurrences of cancer in the brain, and have a better quality of life than similar patients treated with radiotherapy alone.
Journal ArticleDOI
Whole brain radiation therapy with or without stereotactic radiosurgery boost for patients with one to three brain metastases: phase III results of the RTOG 9508 randomised trial
David W. Andrews,Charles B. Scott,Paul W. Sperduto,Adam E. Flanders,Laurie E. Gaspar,Michael C. Schell,Maria Werner-Wasik,W. Demas,J. Ryu,Jean-Paul Bahary,Luis Souhami,Marvin Rotman,Minesh P. Mehta,Walter J. Curran +13 more
TL;DR: WBRT and stereotactic radiosurgery should, therefore, be standard treatment for patients with a single unresectable brain metastasis and considered for Patients with two or three brain metastases.
Journal ArticleDOI
Adjuvant trastuzumab in HER2-positive breast cancer.
Dennis J. Slamon,Wolfgang Eiermann,Nicholas J. Robert,Tadeusz Pienkowski,Miguel Martin,Michael F. Press,John R. Mackey,John A. Glaspy,Arlene Chan,M. Pawlicki,Tamás Pintér,Vicente Valero,Mei Ching Liu,Guido Sauter,Gunter von Minckwitz,Frances M. Visco,Valerie Bee,Marc Buyse,Belguendouz Bendahmane,Isabelle Tabah-Fisch,Mary Ann Lindsay,Alessandro Riva,John Crown +22 more
TL;DR: The addition of 1 year of adjuvant trastuzumab significantly improved disease-free and overall survival among women with HER2-positive breast cancer and the risk-benefit ratio favored the nonanthracycline TCH regimen over AC-T plus trastzumab, given its similar efficacy, fewer acute toxic effects, and lower risks of cardiotoxicity and leukemia.