Journal ArticleDOI
Changes in serum N-acetyl-β-hexosaminidase levels after treatment of hypothyroid and hyperthyroid individuals with l-thyroxine and propylthiouracil
TLDR
Alteration of thyroid status, and specifically T4 level is indicated to be a contributing factor in the regulation of serum HEX activity in humans, as evidenced by individual responsiveness to oral administration of this hormone, or inhibitors of its peripheral metabolism.About:
This article is published in Clinica Chimica Acta.The article was published on 1980-11-20. It has received 4 citations till now. The article focuses on the topics: Hormone activity & Propylthiouracil.read more
Citations
More filters
Journal ArticleDOI
Elevated serum angiotensin-converting enzyme in hyperthyroidism
TL;DR: Triiodothyronine failed to enhance the synthesis of angiotensin-converting enzyme in rabbit alveolar macrophages or in human monocytes in culture, suggesting that the increased serum enzyme is a consequence of an effect other than increased angiotENSin- Converting enzyme synthesis.
Journal ArticleDOI
N-acetyl-β-hexosaminidase activity in human breast milk☆
TL;DR: In this article, the lysosomal enzyme N-acetyl-beta-hexosaminidase (HEX) is present in human breast milk and the specific activity of HEX A in the milk changes little with time post partum, because absolute 5.5-fold HEX B specific activity is increased, as absolute levels (per volume) remain constant in the face of decreasing milk protein content.
Journal ArticleDOI
Serum lysosomal acid hydrolase activities in Graves' disease
TL;DR: After antithyroid treatment, the activities of these enzymes returned to normal levels, except for alpha-D-mannosidase, and the interpretation of these changes in serum acid hydrolases activities is controversial.
Journal ArticleDOI
Alterations of carboxypeptidases N activities in patients with thyroid dysfunction.
TL;DR: Elevations of CN1 and CN2 in the hyperthyroid state seem not to be related to underlying immunological processes but to the thyroid hormone excess itself, and in euthyroid women taking estrogens for contraception CN2 was also elevated.
References
More filters
Journal ArticleDOI
Tay-sachs disease. Detection of heterozygotes and homozygotes by serum hexosaminidase assay.
TL;DR: A fluorometric method showed the activity of hexosaminidase A in human serum to be markedly deficient in serum specimens from nine patients with Tay–Sachs disease.
Journal ArticleDOI
Tay‐sachs disease and related disorders: Fractionation of brain N‐acetyl‐β‐hexosaminidase on DEAE‐cellulose
TL;DR: The separation of hexosaminidase components of post-mortem brain grey matter by gradient elution from DEAE-cellulose is described and two major peaks of activity, corresponding to components A and B reported in previous studies, were clearly separated.
Journal ArticleDOI
Relationship of thyroid status and serum N-acetyl-β-glucosaminidase isoenzyme activities in humans
TL;DR: Data from 28 hyperthyroid, hypothyroid, and euthyroid pre- or early puberty females examined for N-acetyl-beta-glucosaminidase (HEX) activity substantiate earlier findings in the rat, wherein thyroxine administration evoked a similar response in the liver.
Related Papers (5)
Correlation of serum triiodothyronine (T3) and thyroxine (T4) with biologic effects of thyroid hormone replacement in propylthiouracil-treated rats.
Roz D. Frumess,P. Reed Larsen +1 more