Journal ArticleDOI
Chemistry of cephalosporin antibiotics. XV. Transformations of penicillin sulfoxide. Synthesis of cephalosporin compounds
Robert B. Morin,Bill G. Jackson,Richard A. Mueller,Edward R. Lavagnino,W. B. Scanlon,Sandra L. Andrews +5 more
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This article is published in Journal of the American Chemical Society.The article was published on 1969-03-12. It has received 156 citations till now. The article focuses on the topics: Cephalosporin Antibiotic & Cephalosporin.read more
Citations
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Journal ArticleDOI
The Pummerer Reaction: Methodology and Strategy for the Synthesis of Heterocyclic Compounds
Scott K. Bur,Albert Padwa +1 more
Journal ArticleDOI
Comparative Stability of Cephalosporins in Aqueous Solution: Kinetics and Mechanisms of Degradation
Tsukinaka Yamana,Akira Tsuji +1 more
TL;DR: The pH-rate profiles near pH 8 for cephaloglycin, cephalexin, and cephradine could be explained by the intramolecular-nucleophilic attack of the side-chain alpha-amino group upon the beta-lactam carbonyls to produce diketopiperazine-type compounds.
Journal ArticleDOI
The enzymes of β-lactam biosynthesis
Refaat B. Hamed,Gomez-Castellanos,Luc Henry,Christian Ducho,Michael A. McDonough,Christopher J. Schofield +5 more
TL;DR: This work reviews knowledge of the pathways leading to β-lactam antibiotics focusing on the mechanisms, structures and biocatalytic applications of the enzymes involved.
Book ChapterDOI
The Mechanisms of Reactions of β-Lactam Antibiotics
TL;DR: It is explained that penicillin was the first naturally occurring antibiotic to be characterized and used in clinical medicine and can be seen as the progenitor of the β-lactam family of antibiotics, which are characterized by the possession of the four-membered β - lactam ring.
Related Papers (5)
Molecular architecture of the cephalosporins. Insights into biological activity based on structural investigations.
Robert M. Sweet,Lawrence F. Dahl +1 more