Showing papers in "Natural Product Reports in 2013"
Alternatives1, John Innes Centre2, University of Bonn3, University of North Carolina at Chapel Hill4, University of Wisconsin-Madison5, University of Utah6, University of Southern California7, University of Edinburgh8, University of Warwick9, Harvard University10, University College Cork11, University of Queensland12, University of Hertfordshire13, University of Potsdam14, University of California, San Diego15, Goethe University Frankfurt16, University of California, San Francisco17, University of Delaware18, Uppsala University19, Medical University of Vienna20, J. Craig Venter Institute21, University of Hawaii at Manoa22, Leibniz Association23, University of Iowa24, University of Aberdeen25, Georgia Institute of Technology26, University of California, Berkeley27, University of Groningen28, Princeton University29, University of Marburg30, University of Illinois at Urbana–Champaign31, Saarland University32, Norwegian University of Life Sciences33, Massey University34, Toyama Prefectural University35, ETH Zurich36, University of Saskatchewan37, Rutgers University38, Scripps Research Institute39, University of Helsinki40, Texas A&M University41, National Institutes of Health42, Technical University of Berlin43, University of Otago44, University of Cambridge45, University of Alberta46, Michigan State University47, Hofstra University48
TL;DR: This review presents recommended nomenclature for the biosynthesis of ribosomally synthesized and post-translationally modified peptides (RiPPs), a rapidly growing class of natural products.
1,560 citations
TL;DR: Methods for proper identification of plant material, problems of post-harvest changes in plantmaterial, extraction methods including application of ionic liquids, de-replication procedures during natural product isolation are discussed by the review.
295 citations
TL;DR: The reactivity of dihydroflavins with molecular oxygen leads to flavin-4a-OOH adducts which then carry out a diverse range of oxygen transfers, including Baeyer-Villiger type ring expansions, olefin epoxidations, halogenations via transient HOCl generation, and an oxidative Favorskii rerrangement during enterocin assembly.
257 citations
TL;DR: This review encompasses the most relevant discoveries on steroid anticancer drugs and leads through the last decade and comprises 668 references.
208 citations
TL;DR: The synergistic and reciprocal benefits of linking these 'omics technologies with robust ethnobotanical and ethnomedical studies of traditional medicines, to provide critically needed improved medicines and treatments that are inexpensive, accessible, safe and reliable are discussed.
195 citations
TL;DR: This review summarises the recent advances in cloning and maintenance of natural product biosynthetic gene clusters for heterologous expression and the efforts fundamental for discovering novel natural products in the post-genomics era, with a focus on polyketide synthases (PKSs) and non-ribosomal polypeptide synthetases (NRPS).
178 citations
TL;DR: This work reviews knowledge of the pathways leading to β-lactam antibiotics focusing on the mechanisms, structures and biocatalytic applications of the enzymes involved.
168 citations
TL;DR: This review will focus on mainly methodology improvements, particularly in pulse sequences, acquisition and processing methods which are particularly relevant to natural product research, with lesser discussion of hardware improvements.
151 citations
TL;DR: A review that focuses on the UV protectants from lichens and their symbiotic partners (lichenized fungi, green alga, cyanobacteria) with regard to their chemical structures and review the physicochemical properties that act as UV filters is proposed.
149 citations
TL;DR: The journey that began with the discovery of epoxomicin and ended with the successful use of carfilzomib in the clinic may be understood to find new insights into the keys for success in natural product-based drug discovery.
129 citations
TL;DR: The approaches discussed here include TLC-based bioautography, HPLC- based assays with on-line, at-line and off-line detection, as well as affinity-based methods, such as frontal affinity chromatography, pulsed ultrafiltration mass spectrometry, imprinted polymers, and affinity capillary electrophoresis.
TL;DR: A public database repository for metabolomics, tools and approaches for statistical analysis of metabolomics data, and methods for integrating these datasets with transcriptomic data to create hypotheses concerning specialized metabolisms that generate the diversity in natural product chemistry are detailed.
TL;DR: This Highlight describes applications of quantum chemical calculations to problems in natural products chemistry, including the elucidation of natural product structures (distinguishing between constitutional isomers, distinguishing between diastereomers, and assigning absolute configuration).
TL;DR: The report highlights achievements and challenges over the past five years and describes stereoselective intra- and inter-molecular conjugate addition of nitrogen-containing nucleophiles, including tandem and cascade processes.
TL;DR: The synthesis of eribulin mesylate from microgram to multi-gram scale through an intramolecular Nozaki-Hiyama-Kishi reaction and key coupling reactions are described.
TL;DR: Those natural compounds (either pure forms or extracts) that have been found to delay cellular senescence or in vivo ageing will be critically reviewed and summarized according to affected cellular signalling pathways.
TL;DR: Application of high throughput screening technologies to natural product samples demands alterations in assay design as well as sample preparation in order to yield meaningful hit structures at the end of the campaign.
TL;DR: Recent advances related to the construction of ADCs, the optimization of ADC safety and efficacy, and the increasingly pivotal roles of natural product payloads in the current and future landscape of ADC therapy are discussed.
TL;DR: The phytochemical profiles of 38 genera of the Hyacinthaceae will be discussed as well as any biological activity associated with both crude extracts and compounds isolated, and the current contribution considers the family at a global level.
TL;DR: This work analyses genomes from anaerobic bacteria for the presence of secondary metabolite biosynthesis gene clusters, in particular those tentatively coding for polyketide synthases and non-ribosomal peptide synthetases.
TL;DR: The impact of copper-catalyzed cross-coupling reactions in natural product synthesis will be overviewed with an emphasis on the evolution of strategies due to copper catalysis, mostly by comparison with alternative tactics and their relative efficiencies.
TL;DR: The emphasis of this review is on the identification of the most bioprospected taxa and regions, as well as on how these trends have shifted over time.
TL;DR: The current understanding of whether O-acyl glucuronide metabolites of carboxylic acids are toxic is summarised, together with other known examples of interaction between glucuronides and macromolecules.
TL;DR: The aim of this article is to highlight the most recent developments of this subset of the xanthone family by detailing the innate challenges of the construction of this class of natural products, new synthetic approaches, and pharmacological data.
TL;DR: The advances during the past four years in understanding the generality and specificity of thiopeptide biosynthesis are discussed, and on this basis, in expanding the structural diversity by pathway engineering is discussed.
TL;DR: Naturally-occurring angular tricyclic benzofuran/isobenzofuran derivatives of fungal origin and related compounds, in which two heterocyclic rings are fused to a central benzenoid moiety, are covered.
TL;DR: This review provides an overview of latest technological developments, discusses the assets and drawbacks of the available hyphenation techniques, and describes typical analytical workflows.
TL;DR: In this review recent progress in the development of heat shock proteins (Hsp90) in oncogenesis is illuminated, with particular emphasis on inhibitors such as geldanamycin and analogues that serve as a natural product show case.
TL;DR: The aim of this review is to present an overview of the chemistry and biology of tiacumicins since their discovery.
TL;DR: An overview of the bioinformatics challenges associated with transcriptome analyses using short read sequences is provided and how to address these issues in plant species that lack a reference genome is addressed.