Chiral Diphenylperhydroindolinol Silyl Ether Catalyzed Domino Oxa‐Michael—Aldol Condensations for the Asymmetric Synthesis of Benzopyrans.

TLDR: Asymmetric domino oxa-Michael-aldol reactions between trans-cinnamaldehydes and salicylic aldehyde derivatives have been developed as mentioned in this paper, using (2 S,3 aS,7 aS )-diphenylperhydro indolinol silyl ether 4i as the catalyst, most corresponding chiral benzopyrans can be obtained with excellent chemo and enantioselectivities.

Abstract: Asymmetric domino oxa-Michael–aldol reactions between trans -cinnamaldehydes and salicylic aldehyde derivatives have been developed. Using (2 S ,3 aS ,7 aS )-diphenylperhydro indolinol silyl ether 4i as the catalyst, most corresponding chiral benzopyrans can be obtained with excellent chemo- and enantioselectivities.