Circulating factors in the etiology of pulmonary insufficiency and right heart failure accompanying severe sepsis (peritonitis).
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This article is published in Annals of Surgery.The article was published on 1970-05-01 and is currently open access. It has received 112 citations till now. The article focuses on the topics: Pulmonary insufficiency & Peritonitis.read more
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Profound but Reversible Myocardial Depression in Patients with Septic Shock
Margaret M. Parker,James H. Shelhamer,Stephen L. Bacharach,Michael V. Green,Charles Natanson,Terri M. Frederick,Barbara A. Damske,Joseph E. Parrillo +7 more
TL;DR: To characterize the role of cardiac function in septic shock, serial radionuclide cineangiographic and hemodynamic evaluations were done on 20 patients with documented septicShock, finding that nonsurvivors had normal initial ejection fractions and ventricular volumes that did not change during serial studies.
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A circulating myocardial depressant substance in humans with septic shock. Septic shock patients with a reduced ejection fraction have a circulating factor that depresses in vitro myocardial cell performance.
Joseph E. Parrillo,C Burch,James H. Shelhamer,Margaret M. Parker,Charles Natanson,W. H. Schuette +5 more
TL;DR: The quantitative and temporal correlation between the decreased left ventricular EF and this serum myocardial depressant substance argues for a pathophysiologic role for this depressant substances in producing the reversible cardiomyopathy seen during septic shock in humans.
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Pulmonary vascular and right ventricular dysfunction in adult critical care: current and emerging options for management: a systematic literature review
TL;DR: Although some recommendations can be made to guide the critical care management of pulmonary vascular and right ventricular dysfunction, within the limitations of this review and the GRADE methodology, the quality of the evidence base is generally low, and further high-quality research is needed.
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Gram-negative bacteremia produces both severe systolic and diastolic cardiac dysfunction in a canine model that simulates human septic shock.
Charles Natanson,M. P. Fink,H K Ballantyne,Thomas J. MacVittie,J. J. Conklin,Joseph E. Parrillo +5 more
TL;DR: Evidence is provided that septic shock produces a profound, but reversible, decrease in systolic ventricular performance and this decreased performance was not seen in controls and was associated with ventricular dilatation.
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Myocardial dysfunction in septic shock.
TL;DR: The therapeutic approach to the patient with cardiac dysfunction in distributive or septic shock must be primarily aimed at reestablishing adequate organ perfusion and oxygen delivery by vigorous fluid resuscitation and vasopressor or inotropic support.
References
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STUDIES ON INFLAMMATION: I. The Effect of Histamine and Serotonin on Vascular Permeability: An Electron Microscopic Study
Guido Majno,G. E. Palade +1 more
TL;DR: The mechanism, whereby histamine and serotonin increase the permeability of blood vessels, was studied in the rat by means of the electron microscope, and electron microscopic findings suggested that the endothelial cells become partially disconnected along the intercellular junctions.
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The ultrastructural basis of capillary permeability studied with peroxidase as a tracer
TL;DR: It is concluded that the endothelial cell junctions are most likely to be the morphological equivalent of the small pore system proposed by physiologists for the passage of small, lipid-insoluble molecules across the endothelium.
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Patterns of septic shock in man--a detailed study of 56 patients.
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Changes in the Blood Coagulation System Associated with Septicemia
TL;DR: Detailed coagulation analyses in 36 pediatric cases of septicemia revealed 22 gram-negative and eight gram-positive infections, two Rocky Mountain spotted fevers, and four with no etiologic agent isolated.