Open AccessJournal Article
Clinical and EEG effects of GB-94, a "tetracyclic" antidepressant (EEG model in discovery of a new psychotropic drug).
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This article is published in Current Therapeutic Research-clinical and Experimental.The article was published on 1972-07-01 and is currently open access. It has received 92 citations till now. The article focuses on the topics: Psychotropic drug & Tetracyclic antidepressant.read more
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Depression: a new animal model sensitive to antidepressant treatments
R D Porsolt,M Le Pichon,M Jalfre +2 more
TL;DR: Results presented below indicate that immobility is reduced by different treatments known to be therapeutic in depression including three drugs, iprindole, mianserin and viloxazine which although clinically active show little or no ‘antidepressant’ activity in the usual animal tests.
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Mianserin: A Review of its Pharmacological Properties and Therapeutic Efficacy in Depressive Illness
TL;DR: Experimental studies in animals indicate that mianserin is less liable to cause cardiotoxicity than the tricyclic drugs, amitriptyline, imipramine or clomipramines, or the modified tricyClic drug maprotiline.
Journal ArticleDOI
Test-retest reliability in EEG frequency analysis.
TL;DR: Peak alpha frequency and mean frequency were the most stable EEG features at either interval and Montage had significant effects on test-retest differences at the 12-16 week interval.
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Brain histamine receptors as targets for antidepressant drugs
Philip D. Kanof,Paul Greengard +1 more
TL;DR: A large number of structurally diverse drugs with clinical antidepressant properties share the ability to act as potent inhibitors of histamine-sensitive adenylate cyclase in cell-free preparations from mammalian brain, which may represent the molecular basis for the antidepressant properties of these compounds.
Journal ArticleDOI
Blockade of presynaptic alpha-receptors and of amine uptake in the rat brain by the antidepressant mianserine.
P. A. Baumann,L Maître +1 more
TL;DR: It appears that mianserine increases the concentration of noradrenaline in the synaptic cleft by blocking the presynaptic α-receptors and inhibiting uptake.