Journal ArticleDOI
Clinical and immunologic evaluations of reactive dye-exposed workers
Hae-Sim Park,Mi Kyung Lee,Byung Ok Kim,Kyung Jong Lee,Jaehoon Roh,Yong Han Moon,Chein Soo Hong +6 more
TLDR
It is suggested that reactive dyes could induce immunologic responses, most likely IgE-mediated, in type 1 hypersensitivity employees working in a reactive-dye industry.Abstract:
To evaluate type 1 hypersensitivity to reactive dyes, its prevalence, and its relationship to respiratory dysfunction, we studied clinical and immunologic features, including skin prick tests RAST, and bronchoprovocation tests, of 309 employees working in a reactive-dye industry Our survey revealed that 78 (252%) employees had work-related lower respiratory symptoms associated with or without nasal, skin, or eye symptoms Among these employees, 38 (487%) had nonspecific bronchial reactivity Thirteen demonstrated immediate (6), dual (6), or late only (1) asthmatic responses after inhalation of four kinds of reactive-dye solutions Twenty-five employees demonstrated immediate skin responses to black GR dye, and 21 reacted to orange 3R Fifty-three employees (17%) had specific serum IgE antibody against black GR and orange 3R-human serum albumin conjugate Specific IgE was detected more frequently in symptomatic employees (30%) and smokers (100%) No association was found between atopy and specific IgE binding The RAST-inhibition tests of black GR revealed significant inhibitions by black GR-human serum albumin conjugate and minimal inhibitions by unconjugated black GR Orange 3R RAST-inhibition tests revealed significant inhibitions by conjugated forms of black GR and orange 3R and some inhibitions by two unconjugated dyes, suggesting an immunologic cross-reactivity between these dyes These findings suggested that reactive dyes could induce immunologic responses, most likely IgE-mediatedread more
Citations
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Journal ArticleDOI
Aetiological agents in occupational asthma
M Chan-Yeung,J L Malo +1 more
TL;DR: In this review, examples of types of agents causing occupational asthma are discussed and a compendium table of aetiological agents is given.
Journal ArticleDOI
Inhalation challenges with agents causing occupational asthma.
Olivier Vandenplas,Jean-Luc Malo +1 more
TL;DR: The methodology of specific inhalation challenge (SIC) with occupational agents is described, with a special emphasis on procedures aimed at increasing the safety and validity of these tests, and the roles of SIC in the diagnosis of OA are outlined.
Journal ArticleDOI
Epidemiology of occupational rhinitis: prevalence, aetiology and determinants.
TL;DR: The prevalence and more common aetiological agents of OR and its relationship with OA are reviewed and exposure, atopy, and smoking are also reviewed as potential determinants of OR.
Journal ArticleDOI
The association of smoking with sensitization to common environmental allergens: results from the European Community Respiratory Health Survey.
TL;DR: The association of smoking with total IgE levels and with sensitization to 3 common environmental allergens in data from the European Community Respiratory Health Survey was determined.
Journal ArticleDOI
The association of age, gender and smoking with total IgE and specific IgE.
TL;DR: Men aged 20-44 years have higher total IgE levels than women of the same age and its association with sensitization to common allergens varies between allergens.
References
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Hyman Chai,Richard S. Farr,Luz A. Froehlich,David A. Mathison,James A. McLean,Richard R. Rosenthal,Albert L. Sheffer,Sheldon L. Spector,Robert G. Townley +8 more
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TL;DR: The present results demonstrate that very low levels of NO2 can adversely affect some asthmatics and could be related to any physical or clinical characteristics of the subjects tested.
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Bronchial hyperirritability in healthy subjects after exposure to ozone.
TL;DR: It is concluded that brief exposure to 0.6 ppm of ozone produces bronchial hyperirritability via cholinergic postganglionic pathways, probably by damaging airway epithelium and thereby sensitizing bronchia irritant receptors.
Journal ArticleDOI
Nonspecific bronchial reactivity in occupational asthma
TL;DR: The findings suggest nonspecific bronchial hyperreactivity is likely to be the consequence rather than the predisposing factor in occupational asthma, and Methacholine inhalation test is a simple, safe, and useful procedure in the initial assessment of patients suspected to have occupational asthma.