S
Stephen Lam
Researcher at University of British Columbia
Publications - 457
Citations - 23121
Stephen Lam is an academic researcher from University of British Columbia. The author has contributed to research in topics: Lung cancer & Cancer. The author has an hindex of 76, co-authored 413 publications receiving 20693 citations. Previous affiliations of Stephen Lam include Solvay & BC Cancer Agency.
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Journal ArticleDOI
Side Population in Human Lung Cancer Cell Lines and Tumors Is Enriched with Stem-like Cancer Cells
TL;DR: Findings indicate that SP is an enriched source of lung tumor-initiating cells with stem cell properties and may be an important target for effective therapy and a useful tool to investigate the tumorigenic process.
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Small-Airway Obstruction and Emphysema in Chronic Obstructive Pulmonary Disease
John E. McDonough,Ren Yuan,Masaru Suzuki,Nazgol Seyednejad,W. Mark Elliott,Pablo G. Sanchez,Alexander C. Wright,Warren B. Gefter,Leslie A. Litzky,Harvey O. Coxson,Peter D. Paré,Don D. Sin,Richard A. Pierce,Jason C. Woods,Annette McWilliams,John R. Mayo,Stephen Lam,Joel D. Cooper,James C. Hogg +18 more
TL;DR: Results show that narrowing and disappearance of small conducting airways before the onset of emphysematous destruction can explain the increased peripheral airway resistance reported in COPD.
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Near-infrared Raman spectroscopy for optical diagnosis of lung cancer
TL;DR: NIR Raman spectroscopy provides significant potential for the noninvasive diagnosis of lung cancers in vivo based on the optic evaluation of biomolecules, according to the results of this exploratory study.
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Localization of Bronchial Intraepithelial Neoplastic Lesions by Fluorescence Bronchoscopy
Stephen Lam,Timothy C. Kennedy,Michael Unger,York E. Miller,David Gelmont,Valerie W. Rusch,Bruce Gipe,David Howard,Jean C. LeRiche,Andrew Coldman,Adi F. Gazdar +10 more
TL;DR: Autofluorescence bronchoscopy, when used as an adjunct to standard WLB, enhances the bronchoscopeopist's ability to localize small neoplastic lesions, especially intraepithelial lesions that may have significant implication in the management of lung cancer in the future.
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Molecular Damage in the Bronchial Epithelium of Current and Former Smokers
Ignacio I. Wistuba,Stephen Lam,Carmen Behrens,Arvind K. Virmani,Kwun M. Fong,Jean C. LeRiche,Jonathan M. Samet,Sudhir Srivastava,John D. Minna,Adi F. Gazdar +9 more
TL;DR: Genetic changes similar to those found in lung cancers can be detected in the nonmalignant bronchial epithelium of current and former smokers and may persist for many years after smoking cessation.