Journal ArticleDOI
Clinical efficacy of amiodarone as an antiarrhythmic agent
Mauricio B. Rosenbaum,Pablo A. Chiale,M. Susana Halpern,Gerardo J. Nau,Julio Przybylski,Raúl J. Levi,Julio O. Lázzari,Marcelo V. Elizari +7 more
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TLDR
Amiodarone proved safe in patients with severe congestive heart failure and severe myocardial damage and liberates patients from a rigid hourly schedule and provides for continuous antiarrhythmic control, days and even weeks after treatment is discontinued.Abstract:
Amiodarone, administered orally in doses of 200 to 600 mg/day, was remarkably effective in the treatment and prevention of a wide variety of atrial and ventricular arrhythmias. Total suppression and control was provided in 98 (92.4 percent) of 106 patients with supraventricular arrhythmias and in 119 (82 percent) of 145 patients with ventricular arrhythmias. The rates of total control of the arrhythmia were: 96.6 percent in 30 patients with recurrent atrial flutter or fibrillation, 96.6 percent in 59 patients with repetitive supraventricular tachycardia, 100 percent in 27 patients with Wolff-Parkinson-White syndrome and 77.2 percent in 44 patients with recurrent ventricular tachycardia unsuccessfully treated with other drugs. Excellent results were obtained in 6 of 8 patients with repetitive ventricular tachycardia and ventricular fibrillation related to postinfarction ventricular aneurysm and in 12 of 14 patients with ventricular extrasystoles and ventricular tachycardia related to Chagasic myocarditis. Amiodarone proved safe in patients with severe congestive heart failure and severe myocardial damage. Its clinical efficacy was related to its electrophysiologic properties and to two unique properties: its wide safety margin and its cumulative effect. The latter liberates patients from a rigid hourly schedule and provides for continuous antiarrhythmic control, days and even weeks after treatment is discontinued.read more
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Antiarrhythmic Agents: The Modulated Receptor Mechanism of Action of Sodium and Calcium Channel-Blocking Drugs
L M Hondeghem,B G Katzung +1 more
TL;DR: This review concentrates on the antiarrhythmic drug literature pertinent to an evaluation of the modulated receptor hypothesis: lidocaine, procainamide, quinidine, diphenylhydantoin, and propranolol.
Journal ArticleDOI
Clinical efficacy and electrophysiology during long-term therapy for recurrent ventricular tachycardia or ventricular fibrillation.
James J. Heger,Eric N. Prystowsky,Warren M. Jackman,Gerald V. Naccarelli,K. A. Warfel,Robert L. Rinkenberger,Douglas P. Zipes +6 more
TL;DR: It is concluded that amiodarone is effective for long-term therapy of recurrent ventricular tachyarrhythmias, that induction of arrhythmia during therapy does not always predict efficacy, and that side effects are frequent but do not usually limit therapy.
Journal ArticleDOI
Adverse Effects of Low Dose Amiodarone: A Meta-Analysis
TL;DR: Exposure to amiodarone in this dose range, for a minimal duration of 12 months, resulted in odds similar to those of placebo for hepatic and gastrointestinal adverse effects, but in significantly higher odds than those of Placebo for experiencing thyroid adverse effects.
Journal ArticleDOI
Prescribing Amiodarone: An Evidence-Based Review of Clinical Indications
TL;DR: Amiodarone should be used with close follow-up in patients who are likely to derive the most benefit, namely those with atrial fibrillation and left ventricular dysfunction, those with acute sustained ventricular arrhythmias, those about to undergo cardiac surgery, and those with implantable cardioverter-defibrillators and symptomatic shocks.
Journal ArticleDOI
Side effects of long-term amiodarone therapy.
TL;DR: Important effects were seen particularly in the thyroid gland, liver, lung and skin, and corneal microdeposits were always found when sought, but did not cause impairment of visual acuity.
References
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The effect of amiodarone, a new anti‐anginal drug, on cardiac muscle
TL;DR: It was concluded that amiodarone had effects on cardiac action potentials similar to those which occur after thyroidectomy.