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Journal ArticleDOI

Control of Tachyarrhythmias Associated with Wolff-Parkinson-White Syndrome by Amiodarone Hydrochloride

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TLDR
Amiodarone hydrochloride proved to be highly effective in preventing and treating arrhythias of the Wolff-Parkinson-White (WPW) syndrome in 11 patients with WPW conduction and recurrent tachyarrhythmias.
Abstract
Amiodarone hydrochloride proved to be highly effective in preventing and treating arrhythmias of the Wolff-Parkinson-White (WPW) syndrome in 11 patients with WPW conduction and recurrent tachyarrhythmias Paroxysmal supraventricular tachycardia (six patients), atrial fibrillation (four patients) and atrial flutter (one patient) were the most significant arrhythmias In most patients the arrhythmia was seriously disabling because of the extremely rapid ventricular rate, adverse hemodynamic consequences and frequent recurrence and long duration of the episodes Other known antiarrhythmic agents were ineffective In all 11 patients amiodarone, in doses of 300 to 600 mg daily, totally, easily and safety controlled the arrhythmias for periods of 2 to 8 months The drug was fully effective after an average of 7 days of treatment Tolerance to amiodarone was excellent The occurrence of corneal microdeposits of the drug was the only Important undesirable effect, but subjective ocular disturbances were not noted The microdeposits are reversible, and can be avoided by discontinuing the drug for 7 days every 1 to 2 months Amiodarone apparently causes a significant prolongation of refractoriness in the normal (A-V node and His-Purkinje system) as well as in the anomalous pathway, thus creating favorable conditions for prevention and Interruption of any reentry mechanism requiring participation of both pathways

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Citations
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Journal ArticleDOI

The preexcitation syndromes.

TL;DR: Surgery offers a feasible therapeutic alternative for patients with life-threatening or disabling arrhythmias but demands a team equipped to perform precise preoperative and intraoperative mapping studies to define the type and location of underlying anatomic substrates.
Journal ArticleDOI

A Classification of Antiarrhythmic Actions Reassessed After a Decade of New Drugs

TL;DR: All but one of the new antiarrhythmic drugs introduced since 1972 have turned out to possess one or more of the four classes of action originally described, and recent research suggests that inhibition of slow inward current may lead, as a secondary consequence of lowered [Ca]i, to improved cell-to-cell conduction.
References
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Journal ArticleDOI

The effect of amiodarone, a new anti‐anginal drug, on cardiac muscle

TL;DR: It was concluded that amiodarone had effects on cardiac action potentials similar to those which occur after thyroidectomy.
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The Role of Premature Beats in the Initiation and the Termination of Supraventricular Tachycardia in the Wolff-Parkinson-White Syndrome

TL;DR: In four patients with WPW syndrome atrial and ventricular premature beats were induced and the changes in form of the ventricular and atrial complexes were studied, results suggest that a circus movement involving the atria, the normal atrioventricular conduction system and the Kent bundle is present.
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Successful Surgical Interruption of the Bundle of Kent in a Patient with Wolff-Parkinson-White Syndrome

TL;DR: Surgical transection of the atrioventricular junction at that point abolished the electrocardiographic features of WPW and the recurrent tachycardia, and five months after surgery the signs and symptoms of congestive heart failure have subsided, and the patient has returned to work.
Journal ArticleDOI

Ventricular fibrillation. A possible mechanism of sudden death in patients and Wolff-Parkinson-White syndrome.

TL;DR: The control of recurrent ventricular fibrillation with large doses of digitalis and other antiarrhythmic drugs, including propranolol, lidocaine, procainamide, and quinidine, is discussed.
Journal ArticleDOI

Epicardial Excitation of the Ventricles in a Patient with Wolff-Parkinson-White Syndrome (Type B)

TL;DR: Epicardial excitation was explored by means of an exploring electrode during operation on a patient with a large atrial septal defect of the secundum type, whose ECG indicated a Wolff-Parkinson-White syndrome of type B.
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