Clonal analysis of palmar fibromatosis: a study whether palmar fibromatosis is a real tumor
Lei Wang,Hongguang Zhu +1 more
Reads0
Chats0
TLDR
It is suggested that palmar fibromatosis is a reactive proliferation rather than a clonal neoplasm, suggesting polyclonality of these lesions.Abstract:
Background
Palmar fibromatosis that arises in the palmar soft tissue is characterized by infiltrative growth with a tendency toward local recurrence but does not metastasize. This study investigated the clonality of this process in twelve female patients, each with a single lesion, by examining the pattern of X-chromosome inactivation.read more
Citations
More filters
Journal ArticleDOI
Detection of beta-catenin mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): An ancillary diagnostic tool
Maria Fernanda Amary,Patrick Pauwels,Els V. Meulemans,Guido M.J.M. Roemen,Lily Islam,Bernadine Idowu,Konstantinos Bousdras,Timothy C. Diss,Paul O'Donnell,Adrienne M. Flanagan +9 more
TL;DR: Mutation-specific restriction enzyme digestion, a simple and efficient means of detecting the common β-catenin mutations in desmoid-type fibromatosis, complements light microscopy in reaching a diagnosis.
Journal Article
Detection of b-catenin gene mutations in paraffin-embedded sporadic desmoid-type fibromatosis by mutation-specific restriction enzyme digestion (MSRED): An ancillary diagnostic tool
Mfc Amary,Bernadine Idowu,Lily Islam,Konstantinos Bousdras,Patrick Pauwels,Els V. Meulemans,Tc Diss,Am Flanagan +7 more
Journal ArticleDOI
Systemic Erdheim-Chester disease.
Brendan C. Dickson,Brendan C. Dickson,Vaijayanti Pethe,Vaijayanti Pethe,Catherine T. Chung,Catherine T. Chung,David Howarth,David Howarth,Juan M. Bilbao,Victor Fornasier,Victor Fornasier,Catherine J. Streutker,Catherine J. Streutker,Linda Sugar,Bharati Bapat,Bharati Bapat +15 more
TL;DR: In confirming clonality, the observations lend additional evidence to the view that Erdheim–Chester disease represents a neoplastic process, and the histiocytes to express CD163, thereby further supporting a monocyte/macrophage basis.
Journal ArticleDOI
Apport de l'échographie dans la maladie de Dupuytren
TL;DR: In this paper, the authors used the palmar fascia at the distal palmar crease, especially at the level of the third and fourth rays with progressive disabling finger contracture, to diagnose Dupuytren's contracture.
References
More filters
Journal ArticleDOI
The clonal evolution of tumor cell populations
TL;DR: Each patient's cancer may require individual specific therapy, and even this may be thwarted by emergence of a genetically variant subline resistant to the treatment, which should be directed toward understanding and controlling the evolutionary process in tumors before it reaches the late stage usually seen in clinical cancer.
Pathology and genetics of tumors of soft tissue and bone
TL;DR: This list includes tumours of undefined neoplastic nature, which are of uncertain differentiation Bone Tumours, Ewing sarcoma/Primitive neuroedtodermal tumour, Myogenic, lipogenic, neural and epithelial tumours, and others.
Journal ArticleDOI
Gene Action in the X -chromosome of the Mouse ( Mus musculus L.)
TL;DR: Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyKnotic and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome.
World Health Organization Classification of Tumours. Pathology and Genetics of Tumours of Soft Tissue and Bone
TL;DR: The fifth volume in the new WHO series on histological and genetic typing of human tumours is "Pathology and Genetics of Tumours of Soft Tissue and Bone" as discussed by the authors.
Journal Article
Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation.
TL;DR: The human androgen-receptor gene (HUMARA) contains a highly polymorphic trinucleotide repeat in the first exon that correlates with X inactivation, and the development of a PCR assay that distinguishes between the maternal and paternal alleles and identifies their methylation status is developed.