Journal ArticleDOI
Gene Action in the X -chromosome of the Mouse ( Mus musculus L.)
TLDR
Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyKnotic and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome.Abstract:
Ohno and Hauschka1 showed that in female mice one chromosome of mammary carcinoma cells and of normal diploid cells of the ovary, mammary gland and liver was heteropyknotic. They interpreted this chromosome as an X-chromosome and suggested that the so-called sex chromatin was composed of one heteropyknotic X-chromosome. They left open the question whether the heteropyknosis was shown by the paternal X-chromosome only, or the chromosome from either parent indifferently.read more
Citations
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X-inactivation profile reveals extensive variability in X-linked gene expression in females
TL;DR: A comprehensive X-inactivation profile of the human X chromosome is presented, representing an estimated 95% of assayable genes in fibroblast-based test systems, and suggests a remarkable and previously unsuspected degree of expression heterogeneity among females.
Journal ArticleDOI
The molecular hallmarks of epigenetic control
C. David Allis,Thomas Jenuwein +1 more
TL;DR: A personal perspective on the development of epigenetics, from its historical origins to what is defined as 'the modern era of epigenetic research', is provided.
Journal ArticleDOI
Chromosomal subunits in active genes have an altered conformation
Harold Weintraub,Mark Groudine +1 more
TL;DR: The results indicate that active genes are probably associated with histones in a subunit conformation in which the associated DNA is particularly sensitive to digestion by deoxyribonuclease I.
Journal ArticleDOI
Long noncoding RNAs: past, present, and future.
TL;DR: The current state of knowledge of the lncRNA field is reviewed, discussing what is known about the genomic contexts, biological functions, and mechanisms of action of lncRNAs and how this interest is deeply rooted in biology's longstanding concern with the evolution and function of genomes.
References
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Journal ArticleDOI
Formation of the sex chromatin by a single X-chromosome in liver cells of Rattus norvegicus.
Journal ArticleDOI
The y-chromosome as the bearer of male determining factors in the mouse.
W. J. Welshons,Liane B. Russell +1 more
Journal Article
Allocycly of the x-chromosome in tumors and normal tissues.
Susumu Ohno,T S Hauschka +1 more
TL;DR: A single, deeply staining heteropyknotic chromosome, most conspicuous during prophase in neoplastic and normal diploid female cells of mouse and rat, is interpreted as one of the two X-chromosomes, which has a bearing on the constitution of the “sex chromatin” in interphase nuclei which is usually composed of the heterochromatin of a single positively heteropycly X, rather than two paired X9s.
Journal ArticleDOI
Jimpy, a new totally sexlinked gene in the house mouse.
TL;DR: A new recessive mutant jimpy, jp, is described, situated on the differential segment of the sex chromosome and is lethal in the hemizygous condition and shows about 21% recombination with Ta and 36% with Bn.