Journal ArticleDOI
Cold urticaria. Immunologic studies.
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Absorption studies showed that the passive transfer activity could be removed from the four serum specimens by monospecific antisersum to IgE but not by antiserum to any of the other immunoglobulins, quite similar to those of IgE skin-sensitizing antibodies.About:
This article is published in The American Journal of Medicine.The article was published on 1970-07-01. It has received 109 citations till now. The article focuses on the topics: Antiserum & Immunoglobulin E.read more
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Journal ArticleDOI
Biologic and clinical significance of cryoglobulins. A report of 86 cases.
TL;DR: In this series, immunoproliferative and autoimmune disorders were the most frequent diseases associated with cryoglobulinemia and no treatment was definitively effective in patients with chronic symptoms such as vascular purpura.
Book Chapter
Urticaria and Angioedema
TL;DR: The histopathological features of urticaria are dilatation of cutaneous blood vessels and lymphatics in the superficial dermis, widening of dermal papillae, flattening of rete pegs, and swelling of collagen fibers.
Journal ArticleDOI
Cold Urticaria: Release into the Circulation of Histamine and Eosinophil Chemotactic Factor of Anaphylaxis during Cold Challenge
TL;DR: This initial observation of release of eosinophil chemotactic factor of anaphylaxis in vivo along with histamine assigns the mast cell a central role in cold urticaria.
Journal ArticleDOI
Prevalence and functional role of anti-IgE autoantibodies in urticarial syndromes
Barry L. Gruber,Barry L. Gruber,Maria L. Baeza,Maria L. Baeza,Mary J. Marchese,Mary J. Marchese,Vincent. Agnello,Vincent. Agnello,Allen P. Kaplan,Allen P. Kaplan +9 more
TL;DR: Sera containing IgG anti-IgE antibodies gave a strongly positive transfer test at 5 h but not 48 h, suggesting a pathogenic role for the IgG, and several positive sera were capable of inducing histamine release from normal peripheral basophils and caused a wheal-flare response upon intradermal injection.
Journal ArticleDOI
Exercise-induced anaphylaxis
TL;DR: The clinical manifestations of exercise-induced anaphylaxis are reviewed, and food-related factors contributing to the disorder are considered.
References
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Journal ArticleDOI
Diagnosis of allergy by an in-vitro test for allergen antibodies.
TL;DR: The results strongly support the hypothesis that reagins belong to the immunoglobulin class IgND, provisionally called IgND.
Journal Article
Identification of gamma-E-antibodies as a carrier of reaginic activity
TL;DR: Evidence was presented that reaginic antibody against antigen E in the serum of one individual was γE-globulin of mostly κ chain type, which is associated withReaginic activity of the final preparation was about 1000 times more active than the original sera and the most active fraction gave positive P-K reactions at a dilution of 1:80,000.
Journal Article
Physico-Chemical Properties of Human Reaginic Antibody: IV. Presence of a Unique Immunoglobulin as a Carrier of Reaginic Activity
TL;DR: The results highly suggest that the reaginic activity is associated with γE-globulin, a unique γ1-immunoglobulin tentatively designated by radioimmunoelectrophoresis and byRadioimmunodiffusion.
Journal Article
Immunological studies of an atypical (myeloma) immunoglobulin.
S. G. O. Johansson,H. Bennich +1 more
TL;DR: An 8S myeloma component, isolated from serum of a patient with myelomatosis is described, which appears to have no antigenic determinants in common with human, α-, δ-, γ- or μ-polypeptide chains as revealed by immuno-electrophoresis and Ouchterlony gel diffusion analysis.