Journal ArticleDOI
Compactibility improvement of metformin hydrochloride by crystallization technique
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TLDR
In this paper, a 3 2 full factorial design (FFD) was employed for optimization of the processing parameters of metformin HCl by adopting particle engineering technique, which showed impressive improvement in flow property, compressibility as well as compactibility.About:
This article is published in Advanced Powder Technology.The article was published on 2012-11-01. It has received 28 citations till now. The article focuses on the topics: Crystallization.read more
Citations
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Composite particles based on particle engineering for direct compaction
TL;DR: Improved functionality of co-processed particles and corresponding mechanisms were summarized and discussed from the perspective of structure characteristics (Crystal level and Particle level) as the properties of particles are markedly affected by their structure.
Journal ArticleDOI
Expedited development of a high dose orally disintegrating metformin tablet enabled by sweet salt formation with acesulfame.
TL;DR: A sweet salt of metformin with acesulfame, prepared though an anion exchange reaction, showed superior properties over the commercial hydrochloride salt, which was explained by the different crystal structures and lower hardness as measured by nanoindentation.
Journal ArticleDOI
Recent Advances in Co-processed APIs and Proposals for Enabling Commercialization of These Transformative Technologies.
Luke Schenck,Deniz Erdemir,Lindsey Saunders Gorka,Jeremy M. Merritt,Ivan Marziano,Raimundo Ho,Mei Lee,Joseph W. Bullard,Moussa Boukerche,Steven Ferguson,Alastair J. Florence,Saif A. Khan,Changquan Calvin Sun +12 more
TL;DR: This work will highlight reasons why co-processed APIs would best be considered as drug substances from a regulatory perspective and emphasize the areas where regulatory strategies need to be established, in order to allow for commercialization of innovative approaches in this area.
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Flow, packing and compaction properties of novel coprocessed multifunctional directly compressible excipients prepared from tapioca starch and mannitol.
TL;DR: It is concluded that coprocessing tapioca starch and mannitol will enhance the flow, packing and compaction properties of the novel excipient and that the co-fusion method of coprocessioning would produce novel excipients with enhanced direct compression potential compared to the co,grinding method.
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Co-spray drying of metformin hydrochloride with polymers to improve compaction behavior
TL;DR: In this article, the ability of different hydrophilic polymers to improve compression behavior of metformin hydrochloride after co-spray drying from aqueous solutions was investigated.
References
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Journal ArticleDOI
Determination of tablet strength by the diametral compression test
John T. Fell,JM Newton +1 more
TL;DR: It has been shown that to obtain reproducible results for the strength of tablets prepared at a given compression force, the tablet must break in such a manner that the tensile stress is the major stress.
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Some considerations on powder compression equations
Kimio Kawakita,Karl-Helmut Lüdde +1 more
TL;DR: There are two approaches to the problem of powder compression: (a) an observation of the relationship between pressure and volume, and (b) the distribution of internal stress and density as mentioned in this paper.
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The spray drying of pharmaceuticals
TL;DR: The spray drying of pharmaceuticals was studied in this article, where the authors present a spray-drying technique for spray-wading of pharmaceutical drugs, which is called spray drying.