Journal ArticleDOI
Comparative pharmacokinetics of doxycycline in cats and dogs
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TLDR
The disposition of doxycycline hyclate was studied in six adult mixed-breed female cats and six adult mid-sized female dogs following a single intravenous administration of 5 mg/kg body weight.Abstract:
The disposition of doxycycline hyclate was studied in six adult mixed-breed female cats and six adult mid-sized female dogs following a single intravenous administration of 5 mg/kg body weight. Doxycycline volume of the central compartment, area volume of distribution, volume of distribution at steady state, and total body clearance were significantly smaller in cats. The differences were attributed to more extensive binding of doxycycline to plasma protein including albumin in cats. The significant differences in the volume of distribution and total body clearance were not reflected in elimination half-lives under the conditions of this study (sample size, inhomogeneous population). Doxycycline elimination half-life was 4.56 +/- 0.68 (SEM) h for cats and 6.99 +/- 1.09 h for dogs. Dosage regimens recommended in the veterinary literature were evaluated by the computer program PETDR.read more
Citations
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Efficacy of enrofloxacin or doxycycline for treatment of Bartonella henselae or Bartonella clarridgeiae infection in cats.
TL;DR: The results suggest that MICs obtained with axenic media do not predict antimicrobial activity against intracellular Bartonella, that a long treatment course is required to eliminate infection, and that duration of therapy correlates with pretreatment bacterial load.
Journal ArticleDOI
Pharmacokinetics and tissue distribution of doxycycline after oral administration of single and multiple doses in horses
TL;DR: Results suggest that doxycycline administered at a dosage of 20 mg/kg, PO, every 24 hours will result in drug concentrations adequate for killing intracellular bacteria and bacteria with minimum inhibitory concentration < or = 0.25 microg/mL.
Journal ArticleDOI
Mathematical modeling and simulation in animal health - Part II: principles, methods, applications, and value of physiologically based pharmacokinetic modeling in veterinary medicine and food safety assessment.
TL;DR: This review provides a comprehensive summary of PBPK modeling principles, model development methodology, and the current applications in veterinary medicine, with a focus on predictions of drug tissue residues and withdrawal times in food-producing animals.
Journal ArticleDOI
Pharmacokinetics of doxycycline in broiler chickens
Arturo Anadón,María Rosa Martínez-Larrañaga,María José Fernández Díaz,P. Bringas,M.C. Fernandez,María Luisa Fernández-Cruz,J Iturbe,María-Aránzazu Martínez +7 more
TL;DR: The results indicate that doxycycline concentrations were cleared slowly and were at or below the accepted drug tolerance levels in the marker tissues within 5 days after dosing.
Journal ArticleDOI
Study of intragastric administration of doxycycline: pharmacokinetics including body fluid, endometrial and minimum inhibitory concentrations
TL;DR: Based on drug concentrations achieved in the serum, synovial and peritoneal fluids and endometrial tissues and MIC values determined, doxycycline at a dose of 10 mg/kg bwt per os every 12 h may be appropriate for the treatment of infections caused by susceptible (MIC < 0.25 microg/ml) gram-positive organisms in horses.
References
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Journal ArticleDOI
Relation Between Lipophilicity and Pharmacological Behavior of Minocycline, Doxycycline, Tetracycline, and Oxytetracycline in Dogs
TL;DR: It is indicated that lipophilicity correlates with many, but not all, of the transport characteristics of tetracycline antibiotics.
Journal Article
Pharmacotherapeutics of the newer tetracyclines.
TL;DR: The superiority of doxycycline and minocycline in their distribution to areas of he body such as the eye, brain, cerebrospinal fluid, and prostate gland suggests that trials of their efficacy in tetracycline-sensitive infections of these areas are indicated.
Journal ArticleDOI
Apparent volumes of distribution and drug binding to plasma proteins and tissues
TL;DR: A pharmacokinetic model that incorporates linear binding of drug to plasma proteins and tissue indicates the same relationship between apparent volume of distribution and drug binding as that proposed by Gillette (1971) based on a simple distribution model.
Journal Article
Pharmacology and toxicology of doxycycline.
J L Riond,Jim E. Riviere +1 more
TL;DR: The pharmacology, toxicology and therapeutics of doxycycline in laboratory animals and man indicate that this drug may be a valuable antimicrobial for use in veterinary medicine.
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