Journal ArticleDOI
Comparison of Lavandula angustifolia Mill. tincture and imipramine in the treatment of mild to moderate depression: a double-blind, randomized trial
Shahin Akhondzadeh,Ladan Kashani,Akbar Fotouhi,Soghra Jarvandi,Mansour Mobaseri,Mahdiyeh Moin,M Khani,A H Jamshidi,Kambiz Baghalian,Mitra Taghizadeh +9 more
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TLDR
The main overall finding from this study is that lavandula tincture may be of therapeutic benefit in the management of mild to moderate depression as adjuvant therapy.Abstract:
Depression is a major health problem and is not only underrecognized and undertreated but is associated with significant morbidity and mortality. Lavandula angustifolia Mill. (Lamiacae) is used to treat depression. Many medicinal plant textbooks refer to this indication, whereas there is no evidence-based document. Our objective was to compare the efficacy of tincture of L. angustifolia with imipramine in the treatment of mild to moderate depression and to evaluate the possible adjuvant effect of this tincture in a 4 week double-blind, randomized trial. Forty-five adult outpatients who met the Diagnostic and Statistical Manual of Mental Disorders, 4th edition, for major depression based on the structured clinical interview for DSM IV participated in the trial. Patients have a baseline Hamilton Rating Scale for Depression score of at least 18. In this double-blind, single-center trial, patients were randomly assigned to receive lavandula tincture (1:5 in 50% alcohol ) 60 drops/day plus placebo tablet (Group A), tablet imipramine 100 mg/day plus placebo drop (Group B) and tablet imipramine 100 mg/day plus lavandula tincture 60 drops/day (Group C) for a 4-week study. In this small preliminary double-blind and randomized trial, lavandula tincture at this concentration was found to be less effective than imipramine in the treatment of mild to moderate depression (F=13.16, df=1, P=.001). In the imipramine group, anticholinergic effects such as dry mouth and urinary retention were observed more often that was predictable, whereas headache was observed more in the lavandula tincture group. A combination of imipramine and lavandula tincture was more effective than imipramine alone (F=20.83, df=1, P<.0001). As this study indicates, one of the advantages of this combination is a better and earlier improvement. The main overall finding from this study is that lavandula tincture may be of therapeutic benefit in the management of mild to moderate depression as adjuvant therapy. A large-scale trial is justified.read more
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Canadian Network for Mood and Anxiety Treatments (CANMAT) Clinical guidelines for the management of major depressive disorder in adults
TL;DR: Some CAM treatments have evidence of benefit in MDD, however, problems with standardization and safety concerns may limit their applicability in clinical practice.
Journal ArticleDOI
Herbal medicine for depression, anxiety and insomnia: A review of psychopharmacology and clinical evidence
TL;DR: A review of the literature was conducted to ascertain mechanisms of action of these botanicals, in addition to a systematic review of controlled clinical trials for treatment of mood, anxiety and sleep disorders, which are common comorbid psychiatric disorders.
Journal ArticleDOI
Canadian Network for Mood and Anxiety Treatments (CANMAT) clinical guidelines for the management of major depressive disorder in adults. I. Classification, burden and principles of management.
Scott B. Patten,Sidney H. Kennedy,Raymond W. Lam,Claire O'Donovan,Marie Filteau,Sagar V. Parikh,Arun V. Ravindran +6 more
TL;DR: This introductory section of the 2009 revised CANMAT guidelines is to provide definitions of the depressive disorders, summarize Canadian data concerning their epidemiology and describe overarching principles of managing these conditions.
Journal ArticleDOI
Lavender and the Nervous System
TL;DR: A survey on current experimental and clinical state of knowledge about the effect of lavender on the nervous system is given.
Journal ArticleDOI
Rosmarinus officinalis L. (rosemary) as therapeutic and prophylactic agent
TL;DR: In vivo and in vitro studies were presented, approaching the therapeutic and prophylactic effects of R. officinalis L. on some physiological disorders caused by biochemical, chemical or biological agents.
References
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Journal ArticleDOI
A rating scale for depression
TL;DR: The present scale has been devised for use only on patients already diagnosed as suffering from affective disorder of depressive type, used for quantifying the results of an interview, and its value depends entirely on the skill of the interviewer in eliciting the necessary information.
Book
Encyclopedia of Common Natural Ingredients: Used in Food, Drugs, and Cosmetics
Albert Y. Leung,Steven Foster +1 more
TL;DR: In this article, the authors present an overview of natural ingredients and their applications in the field of chemical engineering, including the following categories: Natural Ingredients, Chemical Index, and Chemical Index.
Journal ArticleDOI
Aromatherapy: Evidence for Sedative Effects of the Essential Oil of Lavender after Inhalation
TL;DR: The correlation of the motility of the animals to linalool in serum is experimentally proven, thus furnishing evidence of the aromatherapeutical use of herbal pillows employed in folk medicine since ancient times in order to facilitate falling asleep or to minimize stressful situations of man.
Journal ArticleDOI
Pharmacology of antidepressants--characteristics of the ideal drug.
TL;DR: The newer second- generation antidepressants have distinct pharmacologic advantages in comparison with the tricyclic antidepressants and the older second-generation compounds.