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Comprar Clinical Pharmacokinetics: Concepts and Applications, 4/e | Rowland and Tozer | 9780781750097 | Lippincott Williams & Wilkins
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Pharmacokinetic issues for antibiotics in the critically ill patient.
Jason A. Roberts,Jeffrey Lipman +1 more
TL;DR: Knowledge of antibiotic pharmacodynamic properties and the potential altered antibiotic pharmacokinetics in critically ill patients can allow the intensivist to develop individualized dosing regimens.
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Apixaban, an oral, direct factor Xa inhibitor: single dose safety, pharmacokinetics, pharmacodynamics and food effect in healthy subjects
Charles Frost,Jessie Wang,Sunil Nepal,Alan Schuster,Yu Chen Barrett,Rogelio Mosqueda-Garcia,Richard A. Reeves,Frank LaCreta +7 more
TL;DR: To evaluate apixaban single dose safety, tolerability, pharmacokinetics and pharmacodynamics and assess the effect of food on Apixaban pharmacokinetically, a large number of animals were tested.
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Cytochrome P450‐mediated metabolism in the human gut wall
TL;DR: The current state of knowledge of CYP enzyme expression in human small intestine, the role of the gut wall in CYP-mediated metabolism, and how this metabolism limits the bioavailability of orally administered drugs are reviewed.
Journal ArticleDOI
Tissue distribution and elimination after oral and intravenous administration of different titanium dioxide nanoparticles in rats.
Liesbeth Geraets,Agnes G. Oomen,Petra Krystek,Nicklas Raun Jacobsen,Håkan Wallin,Michel Laurentie,Henny W. Verharen,Esther F.A. Brandon,Wim H. de Jong +8 more
TL;DR: The results of the present oral and IV study indicates very low oral bioavailability and slow tissue elimination and limited uptake in combination with slow elimination might result in the long run in potential tissue accumulation.
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The use of biopharmaceutic classification of drugs in drug discovery and development: current status and future extension
TL;DR: Increased awareness of a proper biopharmaceutical characterization of new drugs may in the future result in drug molecules with a sufficiently high permeability, solubility and dissolution rate, and that will automatically increase the importance of the BCS as a regulatory tool over time.