Journal ArticleDOI
Computational biology of the heart , edited by Alexander V. Panfilov and Arun V. Holden. Pp. 416. £70. 1997. ISBN 0 471 96020 9 (John Wiley & Sons).
TLDR
Partial table of contents: Modelling Cardiac Excitation and Excitability (M. Boyett, et al.) and Finite Element Methods for Modelling Impulse Propagation in the Heart.Abstract:
Partial table of contents: Modelling Cardiac Excitation and Excitability (M. Boyett, et al.). Modelling Propagation in Excitable Media (A. Holden & A. Panfilov). Rotors, Fibrillation and Dimensionality (A. Winfree). A Mathematical Model of Cardiac Anatomy (P. Hunter, et al.). Finite Element Methods for Modelling Impulse Propagation in the Heart (J. Rogers, et al.). The Effects of Geometry and Fibre Orientation on Propagation and Extracellular Potentials in Myocardium (J. Keener & A. Panfilov). Forward and Inverse Problems in Electrocardiography (A. van Oosterom). Computational Electromechanics of the Heart (P. Hunter, et al.). Index.read more
Citations
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Journal ArticleDOI
Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias
André G. Kléber,Yoram Rudy +1 more
TL;DR: This review attempts to synthesize results from computer simulations and experimental preparations to define mechanisms and biophysical principles that govern normal and abnormal conduction in the heart.
Journal ArticleDOI
Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: Filament instability and fibrillation.
Flavio H. Fenton,Alain Karma +1 more
TL;DR: The main finding is that rotational anisotropy generates a sufficiently large twist to destabilize a single transmural filament and cause a transition to a wave turbulent state characterized by a high density of chaotically moving filaments.
Journal ArticleDOI
A simple two-variable model of cardiac excitation
TL;DR: In this article, the authors modified the FitzHugh-Nagumo model of an excitable medium so that it describes adequately the dymanics of pulse propagation in the canine myocardium.
Journal ArticleDOI
Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity
TL;DR: A simplified ionic model of the cardiac action potential (AP), which can be fitted to a wide variety of experimentally and numerically obtained mesoscopic characteristics of cardiac tissue, is used to explain many different mechanisms of spiral wave breakup which in principle can occur in cardiac tissue.
Journal ArticleDOI
Spatiotemporal evolution of ventricular fibrillation
Francis X. Witkowski,L. Joshua Leon,Patricia A. Penkoske,Wayne R. Giles,Mark L. Spano,William L. Ditto,Arthur T. Winfree +6 more
TL;DR: High spatial and temporal resolution mapping of optical transmembrane potentials can easily detect transiently erupting rotors during the early phase of ventricular fibrillation, characterized by a relatively high spatiotemporal cross-correlation.
References
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Journal ArticleDOI
Basic Mechanisms of Cardiac Impulse Propagation and Associated Arrhythmias
André G. Kléber,Yoram Rudy +1 more
TL;DR: This review attempts to synthesize results from computer simulations and experimental preparations to define mechanisms and biophysical principles that govern normal and abnormal conduction in the heart.
Journal ArticleDOI
Vortex dynamics in three-dimensional continuous myocardium with fiber rotation: Filament instability and fibrillation.
Flavio H. Fenton,Alain Karma +1 more
TL;DR: The main finding is that rotational anisotropy generates a sufficiently large twist to destabilize a single transmural filament and cause a transition to a wave turbulent state characterized by a high density of chaotically moving filaments.
Journal ArticleDOI
A simple two-variable model of cardiac excitation
TL;DR: In this article, the authors modified the FitzHugh-Nagumo model of an excitable medium so that it describes adequately the dymanics of pulse propagation in the canine myocardium.
Journal ArticleDOI
Multiple mechanisms of spiral wave breakup in a model of cardiac electrical activity
TL;DR: A simplified ionic model of the cardiac action potential (AP), which can be fitted to a wide variety of experimentally and numerically obtained mesoscopic characteristics of cardiac tissue, is used to explain many different mechanisms of spiral wave breakup which in principle can occur in cardiac tissue.
Journal ArticleDOI
Spatiotemporal evolution of ventricular fibrillation
Francis X. Witkowski,L. Joshua Leon,Patricia A. Penkoske,Wayne R. Giles,Mark L. Spano,William L. Ditto,Arthur T. Winfree +6 more
TL;DR: High spatial and temporal resolution mapping of optical transmembrane potentials can easily detect transiently erupting rotors during the early phase of ventricular fibrillation, characterized by a relatively high spatiotemporal cross-correlation.