Patent
Computer-aided techniques for analyzing biological sequences
Derek Bernhart,Ming-Hsiu Ho,Luis Jevons,David J. Lockhart,Michael Mittmann,Macdonald S. Morris,Teresa Webster +6 more
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Abstract:
Computer-aided techniques for analyzing biological sequences like nucleic acids are provided. The computer system may analyze hybridization intensities indicating hybridization affinity between nucleic acid probes and a sample nucleic acid sequence in order to call bases in the sample sequence. Multiple base calls may be combined to form a single base call. Additionally, the computer system may analyze hybridization intensities in order to monitor gene expression or the change in gene expression as compared to a baseline.read more
Citations
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Patent
Computer-aided visualization and analysis system for sequence evaluation
TL;DR: A computer system for analyzing nucleic acid sequences is provided in this article, which is used to perform multiple methods for determining unknown bases by analyzing the fluorescence intensities of hybridized nucleic acids probes.
Patent
Digital counting of individual molecules by stochastic attachment of diverse labels
Stephen P.A. Fodor,Glenn Fu +1 more
TL;DR: In this paper, a stochastic transformation was proposed to reduce the problem of counting molecules from one of locating and identifying identical molecules to a series of binary digital questions detecting whether preprogrammed labels are present.
Patent
Method for comparing copy number of nucleic acid sequences
TL;DR: In this paper, a method for comparing and identifying differences in nucleic acid sequences using a plurality of sequence specific recognition reagents (i.e., probes comprising a nuclei acid complementary to a nucleic amino acid sequence in collections to be compared) bound to a solid surface is presented.
Patent
Gene expression and evaluation system
TL;DR: An efficient and easy to use query system for a gene expression database was proposed in this article, which can easily identify genes or expressed sequence tags whose expression correlates to particular tissue types.
References
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PatentDOI
Expression monitoring by hybridization to high density oligonucleotide arrays
TL;DR: In this article, the authors proposed a method for monitoring the expression levels of a multiplicity of genes by hybridizing a nucleic acid sample to a high density array of oligonucleotide probes and quantifying the hybridized nucleic acids in the array.
Journal ArticleDOI
Light-directed, spatially addressable parallel chemical synthesis.
TL;DR: High-density arrays formed by light-directed synthesis are potentially rich sources of chemical diversity for discovering new ligands that bind to biological receptors and for elucidating principles governing molecular interactions.
Journal ArticleDOI
Accessing Genetic Information with High-Density DNA Arrays
Mark S. Chee,Robert Yang,Earl Hubbell,Anthony Berno,Xiaohua C. Huang,David Stern,Jim Winkler,David J. Lockhart,Macdonald S. Morris,Stephen P. A. Fodor +9 more
TL;DR: The simultaneous analysis of the entire human mitochondrial genome is described here and can be used to address a variety of questions in molecular genetics including gene expression, genetic linkage, and genetic variability.
Patent
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
TL;DR: In this paper, a polypeptide array can be synthesized on a substrate by attaching photoremovable groups to the surface of a substrate, exposing selected regions of the substrate to light to activate those regions, attaching an amino acid monomer with a photoregressive group to the activated regions, and repeating the steps of activation and attachment until the desired length and sequences are synthesized.
Patent
Very large scale immobilized polymer synthesis
TL;DR: In this paper, a method and apparatus for preparation of a substrate containing a plurality of sequences is described, where a set of photoremovable groups are attached to a surface of the substrate and selected regions of the surface are exposed to light so as to activate the selected areas.