Journal ArticleDOI
Construction and expression of a dual vector for chemo-enzymatic synthesis of plant indole alkaloids in Escherichia coli.
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TLDR
Cathenamine reduction by sodium borohydride leading to tetrahydroalstonine revealed the chemo-enzymatic indole alkaloid synthesis, demonstrating functional co-expression of both STR1- and SG-cDNAs.About:
This article is published in Natural Product Research.The article was published on 2010-04-29. It has received 9 citations till now. The article focuses on the topics: Strictosidine synthase & Indole alkaloid.read more
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The Pictet–Spengler Reaction in Nature and in Organic Chemistry
TL;DR: The condensation discovered by Pictet and Spengler is the most important method for the synthesis of alkaloid scaffolds and the power of this synthesis method has been convincingly proven in the construction of stereochemicaly and structurally complex alkaloids.
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Die Pictet‐Spengler‐Reaktion in der Natur und der organischen Chemie
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Trends for diverse production strategies of plant medicinal alkaloids.
Liuqing Yang,Joachim Stöckigt +1 more
TL;DR: Alkaloids represent a large and highly diverse group of low-molecular-weight compounds related only by the presence of a nitrogen atom in a heterocyclic ring, and are organized into groups according to the structure of their carbon skeleton.
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The role of biocatalysis in the asymmetric synthesis of alkaloids.
TL;DR: In this paper, a review summarises different applications of biocatalysis in the asymmetric synthesis of alkaloids and discusses how recent developments and novel enzymes render innovative and efficient chemo-enzymatic production routes possible.
The role of biocatalysis in the asymmetric synthesis of
TL;DR: This article reviews the progress in chemo-enzymatic alkaloid synthesis over the last 25 years, focusing on recent developments that have led to significant improvements in terms of step-economy and yield.
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STUDIES ON LYSOGENESIS I.: The Mode of Phage Liberation by Lysogenic Escherichia coli
TL;DR: Observations on a lysogenic strain of Escherichia coli that carries more than one detectable type of phage that is associated with bacteriophage infection followed by lysis of the infected cell are reported.
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Lysogeny at mid-twentieth century: P1, P2, and other experimental systems.
TL;DR: The concept of "experimental system" as introduced and used by Hans-Jorg Rheinberger, a historian of science, may be easily adapted to the present narrative, which proceeds from a personal view rather than from a critical historical examination.
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Alkaloid biosynthesis- the basis for metabolic engineering of medicinal plants
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Microbial production of plant benzylisoquinoline alkaloids
Hiromichi Minami,Ju-Sung Kim,Nobuhiro Ikezawa,Tomoya Takemura,Takane Katayama,Hidehiko Kumagai,Fumihiko Sato +6 more
TL;DR: The synthesis of (S)-reticuline from dopamine by crude enzymes from transgenic Escherichia coli indicates that microbial systems that incorporate plant genes cannot only enable the mass production of scarce benzylisoquinoline alkaloid alkaloids but may also open up pathways for the production of novel benzylcolysis of tyrosine.
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Metabolic engineering for plant natural product biosynthesis in microbes
TL;DR: Reconstruction of biosynthetic pathways in heterologous microorganisms offers significant promise for a scalable means to provide sufficient quantities of a desired NP while using inexpensive renewable resources.