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Control of cell growth and proliferation
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Journal ArticleDOI
Distribution and modulation of the cellular receptor for transforming growth factor-beta.
TL;DR: The biologically inactive form of TGF-beta, which constitutes greater than 98% of autocrine T GF-beta secreted by all of the twelve different cell types assayed, was shown to be unable to bind to the receptor without prior activation in vitro, and it is proposed that this may prevent premature interaction of Autocrine ligand and receptor in the Golgi apparatus.
Journal ArticleDOI
Expression of dominant-negative ErbB2 in the mammary gland of transgenic mice reveals a role in lobuloalveolar development and lactation.
Frank Jones,David F. Stern +1 more
TL;DR: It is demonstrated that ErbB2 signaling is required for proper mammary development and lactation at parturition and at 1 day post-partum, lactationally active, distended lobuloalveoli failed to form.
Journal ArticleDOI
Prolactin and mammary gland development.
TL;DR: Disruption of the genes for PRLand the PRL receptor, as well as those for transcription factors important in mammary gland regulation(Stat proteins), have provided a new set of animal models with which to study normal mammary glands development and the relationships of PRL to breastcarcinogenesis.
Book ChapterDOI
Regulation of development of the normal mammary gland by hormones and growth factors.
TL;DR: During the life cycle of a female mammal, the mammary glands must first undergo morphogenesis to prepare for pregnancy-induced lactogenesis, followed by lactation and involution, which continues and repeats with each subsequent pregnancy.
Book ChapterDOI
Epidermal growth factor and transforming growth factor-alpha in the development of epithelial-mesenchymal organs of the mouse.
TL;DR: There is a substantial amount of evidence that EGF-like growth factors have a physiological role in organ development and that the action of EGF or TGF-α in the development of epithelial-mesenchymal organs is associated with tissue interactions that guide morphogenesis and differentiation.
Related Papers (5)
Epidermal growth factor requirement for development of cultured mammary gland.
Quentin J. Tonelli,Sam Sorof +1 more