Journal ArticleDOI
Cooperating and controlling functions of thymus-derived lymphocytes in relation to autoimmunity.
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TLDR
Evidence is presented that T cells can exert specific feedback control of autoantibody formation and relaxation of T-cell control in ageing humans and experimental animals may be an important contributory factor in the development of autoimmunity.About:
This article is published in The Lancet.The article was published on 1971-07-17. It has received 448 citations till now. The article focuses on the topics: IL-2 receptor & Autoantibody.read more
Citations
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Organ-specific autoimmune diseases induced in mice by elimination of T cell subset. I. Evidence for the active participation of T cells in natural self-tolerance; deficit of a T cell subset as a possible cause of autoimmune disease
TL;DR: The autoimmune disease induced in nude mice was quite similar to human organ-specific autoimmune disease in terms of the spectrum of organs involved, histopathological features, and the development of autoantibodies to corresponding organ components.
Journal ArticleDOI
Angio-immunoblastic lymphadenopathy. Diagnosis and clinical course.
TL;DR: The clinical, laboratory and pathologic manifestations of AILD are consistent with an autoimmune disorder, in which a deficiency of the T-cell regulatory functions probably predisposes to an abnormal proliferative and autoaggressive reaction of the B-cell system.
Journal ArticleDOI
Graft-versus-host reactions: clues to the etiopathology of a spectrum of immunological diseases
E Gleichmann,Steven T. Pals,Anton G. Rolink,Anton G. Rolink,Thadädus Radaszkiewicz,Thadädus Radaszkiewicz,Helga Gleichmann,Helga Gleichmann +7 more
TL;DR: The pathogenesis of parental strain T lymphocytes injected into adult F, mice respond to allogeneic MHC antigens and so induce the symptoms of systemic graft v. host disease (GVHD).
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The spectrum of diseases associated with thymoma. Coincidence or syndrome
TL;DR: Findings merit consideration of thymoma together with certain diseases as a syndrome rather than as a spectrum of coincidental diseases.
Journal ArticleDOI
Evidence of suppressor cell activity in spleens of mice bearing primary tumors induced by moloney sarcoma virus
TL;DR: The data show, that a tumor, although stimulating the immune system, nevertheless may be suppressive on certain immune functions through the activation of suppressor cells.
References
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Book
The clonal selection theory of acquired immunity
TL;DR: The clonal selection theory of acquired immunity is studied as a theory of selection for immunity in the context of infectious disease.
Journal Article
Cell interactions in the induction of tolerance: the role of thymic lymphocytes
R. K. Gershon,K. Kondo +1 more
TL;DR: The induction of tolerance as well as the induction of immunity in thymus dependent BMD cell populations, seems to require the co-operation of TD cells.
Book ChapterDOI
Regulatory effect of antibody on the immune response.
Jonathan W. Uhr,Göran Möller +1 more
TL;DR: This chapter deals with the regulatory effect of antibody on antibody formation, and two mechanisms are described both of which regulate the immune response.
Journal ArticleDOI
Inhibition of Experimental Drug Allergy by Prior Feeding of the Sensitizing Agent
TL;DR: Through the feeding of certain allergenic compounds to the non-sensitive subject, a state of resistance may be established against subsequent experimental sensitization of the skin by the same substance.
Journal ArticleDOI
THE CELLULAR BASIS OF IMMUNOLOGICAL RESPONSES: A Synthesis of Some Current Views
TL;DR: The cooperative function of T-lymphoblasts would account for the relationship often observed between delayed hypersensitivity and humoral-antibody formation, and for the occurrence of allergen-induced blastcell transformation of lymphocytes from allergic patients with anaphylactic - type hypersensitivity.