Demographic, Clinical and Etiological Profile of Young Dystonia Less Than Forty Years of Age – A Hospital Based Study
Reads0
Chats0
TLDR
Familiarity showed that focal dystonia were more common even in younger age group with Writers cramp most common among all dySTONia followed by cervical dystonic followed by writer’s cramp.Abstract:
Objective: To study the demographic, clinical and etiological profile of dystonia in patients less than forty years of age. Material and Methods: In this study two hundred and nineteen patients with different dystonia were included. Data on demographic profile, clinical and etiological profile was recorded and statistical analysis was done by using descriptive analysis (frequency distribution). Results: Out of two hundred and nineteen patients, one hundred thirteen (51.7%) were <26 years of age of onset and one hundred six (48.4%) had >26 years of age of onset with mean age of onset 22.3 years, one hundred seventy six were males and forty four females. Mean duration of illness was 4.4 years. Frequency of different dystonia was focal dystonia 57.72%, multifocal 1.36%, segmental 10%, generalized 29.09%, hemidystonia 3.63% and paroxysmal kinesigenic dystonia 2.72%. Among focal dystoniaWriter’s cramp was most common (63%) followed by cervical dystonia (17.32%), and blepharospasm(7%). Among generalized dystonia Wilson’s disease was most common etiological factor in 31.25% cases. Primary generalized dystonia was seen in 17.2% cases. MRI was abnormal in all eight cases of hemidystonia. SPECT brain was abnormal in 1 out of four cases of paroxysmal kinesigenic dystonia. DYT1 was positive in four out of eleven patients of primary generalized dystonia. Conclusion: Present study showed that focal dystonia were more common even in younger age group with Writers cramp most common among all dystonia followed by cervical dystonia. In hemidystonia structural lesion should always be ruled out.read more
Citations
More filters
CASE REPORT - Dystonia as Presenting Manifestation of Ataxia Telangiectasia : A Case Report
TL;DR: A family of three siblings suffering from ataxia telangiectasia is described, with the proband presented with dystonia and dystonic myoclonus, both of which are rare presenting features of ataxian telangIectasia.
Journal ArticleDOI
Comparative study between idiopathic and non-idiopathic dystonia: a prospective observational study
Rupesh Prasad,Anand Kumar,Abhishek Pathak,Varun Kumar Singh,Ashish Verma,Rameshwar Nath Chaurasia,Vijaya Nath Mishra,Deepika Joshi +7 more
TL;DR: In this article, a comparison of the idiopathic and non-idiopathy dystonias based on the newer classification has not been done previously, and the authors compared the dystonia patients attending a movement disorder clinic of a tertiary care teaching institution.
References
More filters
Journal ArticleDOI
The early-onset torsion dystonia gene (DYT1) encodes an ATP-binding protein
Laurie J. Ozelius,Jeffrey W. Hewett,Curtis E. Page,Susan B. Bressman,Patricia L. Kramer,Christo Shalish,Deborah de Leon,Mitchell F. Brin,Deborah Raymond,David P. Corey,Stanley Fahn,Neil Risch,Alan Buckler,James F. Gusella,Xandra O. Breakefield +14 more
TL;DR: The DYT1 gene on human chromosome 9q34 is identified as being responsible for early-onset torsion dystonia, a movement disorder, characterized by twisting muscle contractures, that begins in childhood.
Journal ArticleDOI
Epidemiology of focal and generalized dystonia in Rochester, Minnesota.
TL;DR: Investigation in the Rochester, Minnesota, population over the period 1950–1982 found that Torticollis was the most common focal dystonia; essential blepharospasm, oromandibular dySTONia, spasmodic dysphonia, and writer's cramp were less common and had roughly equal incidence and prevalence rates.
Journal ArticleDOI
Hemidystonia: a report of 22 patients and a review of the literature.
L. C. Pettigrew,Joseph Jankovic +1 more
TL;DR: Hemidystonia may result from a disconnection between the striatum and the thalamus with relative preservation of the corticospinal pathways in patients with perinatal trauma or childhood injury.