Depletion of glutathione from brain cells in hyponatremia
TLDR
It is demonstrated that rat brain is depleted of the antioxidant glutathione in response to hyponatremia and that osmotically-induced loss of glutATHione makes neuronal cells more susceptible to oxidative injury.About:
This article is published in Kidney International.The article was published on 1996-02-01 and is currently open access. It has received 25 citations till now. The article focuses on the topics: Glutathione & Taurine.read more
Citations
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Journal ArticleDOI
Mechanisms of Ammonia-Induced Astrocyte Swelling
TL;DR: Evidence will be provided that glutamine induces oxidative stress as well as the MPT, and that these events are critical in the development of astrocyte swelling in hyperammonemia.
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The cellular hydration state: a critical determinant for cell death and survival.
TL;DR: The close relationship between osmotic and oxidative stress and the contribution of isoosmotic shrinkage to apoptotic cell death are considered.
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Pathogenetic interplay between osmotic and oxidative stress: the hepatic encephalopathy paradigm.
TL;DR: This review proposes a working model that integrates the pathogenetic action of osmotic and oxidative stresses in HE and suggests astrocyte swelling and RNOS production may constitute an autoamplificatory signaling loop that integrates at least some of the signals released by HE-precipitating factors.
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Hypoosmotic swelling increases protein tyrosine nitration in cultured rat astrocytes.
TL;DR: The view that astrocyte swelling as induced, for example, by toxins relevant for hepatic encephalopathy is sufficient to produce oxidative stress and PTN and thus contributes to altered astroglial and neuronal function is supported.
References
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Journal Article
Protein Measurement with the Folin Phenol Reagent
TL;DR: Procedures are described for measuring protein in solution or after precipitation with acids or other agents, and for the determination of as little as 0.2 gamma of protein.
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Morphology and Growth, Tumorigenicity, and Cytogenetics of Human Neuroblastoma Cells in Continuous Culture
TL;DR: Growth, biochemical, and cytogenetic properties confirmed that the lines comprise malignant cells of neurogenic origin, and were established in cell culture from human metastatic neuroblastoma tissue and maintained in vitro for 1 to 2 years.
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Swelling-induced release of glutamate, aspartate, and taurine from astrocyte cultures
TL;DR: The swelling-induced release of label was inhibited by a number of anion transport inhibitors, one of which has been shown to significantly improve outcome in an experimental brain trauma/hypoxia model in which astrocyte swelling is an early event.
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Osmotic demyelination syndrome following correction of hyponatremia
TL;DR: It is suggested that the osmotic demyelination syndrome is a preventable complication of overly rapid correction of chronic hyponatremia, which developed after the patients presented with severe hypon atremia.
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Hyponatremia: A Prospective Analysis of Its Epidemiology and the Pathogenetic Role of Vasopressin
TL;DR: In edematous and hypovolemic patients, plasma hormonal responses were compatible with baroreceptor-mediated release of vasopressin, and nonosmotic secretion of arginine vasoppressin is a major pathogenetic factor in this electrolyte disturbance.