Open Access
Depression: management of depression in primary and secondary care
TLDR
A guideline for the NHS in England and Wales on the management of depression in primary and secondary care is published.Abstract:
The National Institute for Clinical Excellence and the National Collaborating Centre for Mental Health have published a guideline for the NHS in England and Wales on the management of depression in primary and secondary care.read more
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Journal ArticleDOI
Initial severity and antidepressant benefits: a meta-analysis of data submitted to the Food and Drug Administration.
Irving Kirsch,Brett J. Deacon,Tania B. Huedo-Medina,Alan Scoboria,Thomas J. Moore,Blair T. Johnson +5 more
TL;DR: Drug–placebo differences in antidepressant efficacy increase as a function of baseline severity, but are relatively small even for severely depressed patients.
Unit Costs of Health and Social Care 2014
TL;DR: The 2014 edition of the PSSRU Unit-Costs series as mentioned in this paper is the latest volume in a well-established series bringing together information from a variety of sources to estimate national unit costs for a wide range of health and social care services.
Journal ArticleDOI
Antidepressant Drug Effects and Depression Severity: A Patient-Level Meta-analysis
Jay C. Fournier,Robert J. DeRubeis,Steven D. Hollon,Sona Dimidjian,Jay D. Amsterdam,Richard C. Shelton,Jan Fawcett +6 more
TL;DR: The magnitude of benefit of antidepressant medication compared with placebo increases with severity of depression symptoms and may be minimal or nonexistent, on average, in patients with mild or moderate symptoms.
Journal ArticleDOI
Comparative efficacy and acceptability of 12 new-generation antidepressants: a multiple-treatments meta-analysis
Andrea Cipriani,Andrea Cipriani,Toshiaki A. Furukawa,Georgia Salanti,John R. Geddes,Julian P T Higgins,Rachel Churchill,Norio Watanabe,Atsuo Nakagawa,Ichiro M Omori,Hugh McGuire,Michele Tansella,Corrado Barbui +12 more
TL;DR: Clinically important differences exist between commonly prescribed antidepressants for both efficacy and acceptability in favour of escitalopram and sertraline, which might be the best choice when starting treatment for moderate to severe major depression in adults.
Journal ArticleDOI
A 4-item measure of depression and anxiety: Validation and standardization of the Patient Health Questionnaire-4 (PHQ-4) in the general population.
Bernd Löwe,Inka Wahl,Matthias Rose,Carsten Spitzer,Heide Glaesmer,Katja Wingenfeld,Antonius Schneider,Elmar Brähler +7 more
TL;DR: Results from this study support the reliability and validity of thePHQ-4, PHQ-2, and GAD-2 as ultra-brief measures of depression and anxiety in the general population and can be used to compare a subject's scale score with those determined from a general population reference group.