Journal ArticleDOI
Design and Synthesis of L‐Proline Derivatives as Enantioselective Organocatalysts for Synthesis of the (S)‐Wieland‐Miescher Ketone
Li Pan,Xiaoqin Ding,Junjie Ding,Dayu Li,Ji-sheng Chen,Xialong Zuo,Rong An +6 more
- Vol. 2, Iss: 36, pp 11999-12005
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The article was published on 2017-12-21. It has received 7 citations till now. The article focuses on the topics: Wieland–Miescher ketone & Aldol condensation.read more
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Journal ArticleDOI
Recent developments in next generation (S)-proline-derived chiral organocatalysts
TL;DR: In this paper, an overview of the development of diamine analogs of privileged (S)-prolinols as organocatalysts is presented, and the remarkable influence of solvate ionic liquids as well as the usage of other types of ionic liquid that results in a significant improvement of the catalytic activity of proline is described.
Journal ArticleDOI
Re-Engineering Organocatalysts for Asymmetric Friedel-Crafts Alkylation of Indoles through Computational Studies.
Gabriela Guillermina Gerosa,Maribel O. Marcarino,Rolando A. Spanevello,Alejandra G. Suárez,Ariel M. Sarotti +4 more
TL;DR: The computational results were validated experimentally (up to 92:8 er), providing another successful example of a general strategy to accelerate catalysts development which still remains underexplored.
Journal ArticleDOI
New Mesoporous Silica-Supported Organocatalysts Based on (2S)-(1,2,4-Triazol-3-yl)-Proline: Efficient, Reusable, and Heterogeneous Catalysts for the Asymmetric Aldol Reaction.
TL;DR: The solid-phase silica-bonded catalytic systems described herein allow for a substantial reduction in solvent usage and can be recovered, reactivated, and reused several times with limited loss in catalytic efficiency relative to freshly synthesized organocatalysts.
Journal ArticleDOI
Aspects in the Total Syntheses of Higher Terpenoids Starting From Wieland–Miescher Ketone and Its Derivative: A Review:
TL;DR: Synthetic studies of higher terpenoids starting from Wieland-Miescher ketone since 2012 have been compiled as mentioned in this paper, and the results of these studies are summarized in Table 1.
Book ChapterDOI
Diastereo- and enantioselective synthesis by nontraditional activation methods: Ultrasonic, microwave, electro-, photo- and mechanochemically activated reactions
Manisha Mishra,Béla Török +1 more
TL;DR: In this paper, the authors summarized the developments in the application of nontraditional activation methods for the synthesis of chiral compounds, including microwave assisted organic synthesis, sonochemistry, electrochemical activation, photochemistry, and mechanochemical synthesis.
References
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Journal ArticleDOI
Controlled microwave heating in modern organic synthesis.
TL;DR: This Review highlights recent applications of controlled microwave heating in modern organic synthesis, and discusses some of the underlying phenomena and issues involved.
Journal ArticleDOI
New mechanistic studies on the proline-catalyzed aldol reaction.
TL;DR: An experimental program is initiated with the goal of clarifying some of the basic mechanistic questions concerning the proline-catalyzed aldol reaction and providing further evidence for the involvement of enamine intermediates.
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Computational evidence for the enamine mechanism of intramolecular aldol reactions catalyzed by proline
Journal ArticleDOI
Microwave-assisted asymmetric organocatalysis. A probe for nonthermal microwave effects and the concept of simultaneous cooling.
TL;DR: For all of the studied (S)-proline-catalyzed asymmetric Mannich- and aldol-type reactions, the observed rate enhancements were a consequence of the increased temperatures attained by microwave dielectric heating and were not related to the presence of the microwave field.
Journal ArticleDOI
Short alpha/beta-peptides as catalysts for intra- and intermolecular aldol reactions.
TL;DR: Short alpha/beta-peptides, containing conformationally restricted cis-beta-aminocyclopropylcarboxylic acid units as turn-inducing elements, have been found to be efficient catalysts for inter- and intramolecular aldol reactions.