Journal ArticleDOI
Detection and Identification of Monoamine Oxidase Inhibitors in Biological Samples
A. S. Curry,M. Mercier +1 more
TLDR
These therapeutically valuable drugs are implicated in an increasing number of severe and some times fatal accidents caused either by gross overdosage, producing symptoms of hypernoradrenalinaemia or more frequently by interacting with other drugs such as sympathomimetic amines.Abstract:
THE monoamine oxidase (MAO) inhibitor drugs are now widely used in psychiatric practice for the management of various types of neurotic and psychotic depressions; unfortunately, these therapeutically valuable drugs are implicated in an increasing number of severe and some times fatal accidents caused either by gross overdosage, producing symptoms of hypernoradrenalinaemia1 or more frequently by interacting with other drugs such as sympathomimetic amines2–5, amine precursors6–9, central nervous system depressants10–12 and also with foods containing tyramine, DOPA and other amines13.read more
Citations
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A further insight into the metabolism of certain -carbolines.
R. M. Dajani,S. E. Saheb +1 more
TL;DR: Alcohol appears to be utilized in the formation of most of the metabolites of serotonin and some of these intermediates could be at work in the development of alcohol dependence and in other pharmacological effects of ethanol.
Journal ArticleDOI
The pH-Dependence of the Absorption and Fluorescence Spectra of Harmine and Harmol: Drastic Differences in the Tautomeric Equilibria of Ground and First Excited Singlet State*
Otto S. Wolfbeis,Eva Fürlinger +1 more
Journal ArticleDOI
The TLC-Bioautography as a Tool for Rapid Enzyme Inhibitors detection - A Review.
TL;DR: This review summarizes known TLC-Bioautography methods and their applications for determining the presence of enzyme inhibitors in extracts and compares the effectiveness of different methodological approaches.
Journal ArticleDOI
Effect-directed analysis in food by thin-layer chromatography assays.
TL;DR: Thin-layer chromatography (TLC) is widely used for food analysis and quality control and is compatible with microbial-, biochemical-, and chemical-based derivatization methods as discussed by the authors .
Journal ArticleDOI
A rapid thin-layer chromatography bioautographic method for detecting the monoamine oxidase inhibitors in plants
TL;DR: The present work describes developing a thin-layer chromatography (TLC) bioautographic method for detecting MAO inhibitors from plant extracts with several advantages such as lower consumption of the enzyme, shorter experimental time, more easily observed background of TLC plate and better reproducibility.
References
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Journal ArticleDOI
The histochemical demonstration of monoamine oxidase activity by tetrazolium salts.
TL;DR: Localization of the formazan to autonomic ganglia and fibers, chief cells of the gastric fundus, mucosal epithelium of the duodenum and certain specific zones of the renal tubules by means of the tryptamine-tetrazolium technique was confirmed as indicating monoamine oxidase activity by identical localization using the hydrazone precipitation technique of Koelle and Valk.
Journal ArticleDOI
Monoamine Oxidase Inhibitors, Tyramine, and Cheese
TL;DR: Marked potentiation of the pressor effects of tyramine hydrochloride, given orally and intravenously, was demonstrated in patients receiving a monoamine oxidase (MAO) inhibitor, and one of the hazards of treatment with MAO inhibitors is emphasized.
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Vascular crises associated with monoamine-oxidase inhibitors.
TL;DR: The authors gave 1,223 courses of antidepressant medication, and in 692 courses MAO inhibitors were used, the highest incidence of reactions occurred with tranylcypromine, but nevertheless this drug is being used more frequently than any other MAO inhibitor and is regarded as indispensible in the treatment of depressive illness.
Journal ArticleDOI
Tetrazolium reduction as a measure of monoamine oxidase activity in vitro
TL;DR: Data has been presented showing that tetrazolium salts can be used for the histochemical localization of monoamine oxidase, although there are limitations to its application to in vitro studies.