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Ricardo L. E. Furlan
Researcher at National University of Rosario
Publications - 84
Citations - 2857
Ricardo L. E. Furlan is an academic researcher from National University of Rosario. The author has contributed to research in topics: Dynamic combinatorial chemistry & Tyrosinase. The author has an hindex of 27, co-authored 79 publications receiving 2581 citations. Previous affiliations of Ricardo L. E. Furlan include University of Cambridge & National Scientific and Technical Research Council.
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Selection and Amplification of Hosts From Dynamic Combinatorial Libraries of Macrocyclic Disulfides
TL;DR: This work has discovered two receptors for two different guests from a single dynamic combinatorial library that amplifies the formation of a tightly binding host at the expense of unfit library members.
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Dynamic Combinatorial Libraries of Macrocyclic Disulfides in Water
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Antifungal Chalcones and New Caffeic Acid Esters from Zuccagnia punctata Acting against Soybean Infecting Fungi
Laura Svetaz,Alejandro Tapia,Silvia N. Lopez,Ricardo L. E. Furlan,Elisa M. Petenatti,Rosanna Pioli,Guillermo Schmeda-Hirschmann,S. Zacchino +7 more
TL;DR: Assay guided fractionation led to the isolation of two chalcones, one flavanone and a new caffeoyl ester derivative as the compounds responsible for the antifungal activity of Zuccagnia punctata.
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Recent developments in dynamic combinatorial chemistry
TL;DR: Proof of principle of this approach has been established using small libraries showing highly efficient amplification of selected receptors, which has recently been extended to address folding of macromolecules, including peptides.
Journal ArticleDOI
Dynamic combinatorial chemistry.
TL;DR: A combinatorial library that responds to its target by increasing the concentration of strong binders at the expense of weak binders sounds ideal, and could make a useful addition to the set of combinatorsial techniques used in drug discovery.