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Dietary cholesterol, serum cholesterol, and risks of cardiovascular and noncardiovascular diseases. authors' replies

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This article is published in The American Journal of Clinical Nutrition.The article was published on 1998-01-01 and is currently open access. It has received 7 citations till now.

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The Impact of Egg Limitations on Coronary Heart Disease Risk: Do the Numbers Add Up?

TL;DR: Dietary effects on plasma cholesterol must be viewed from effects on the atherogenic LDL cholesterol as well as anti-atherogenic HDL cholesterol since the ratio of LDL:HDL cholesterol is a major determinant of heart disease risk.
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Dietary fibre and cardiovascular health

TL;DR: The present paper analyzes the effects of fibre consumption on cholesterol and lipoprotein levels; systolic and diastolic blood pressures; and antioxidant availability and profile; and the possible mechanisms by which fibre may decrease plasma total cholesterol and LDL-cholesterol and blood pressure and to act as antioxidant, as well.
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Genes, variation of cholesterol and fat intake and serum lipids.

TL;DR: Current evidence suggests that APOE might be responsible for some of the interindividual variability in dietary response, and other loci, including APOA4, APOA1 and APOB have also been found to account for some the variability in the fasting and fed states.
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Cholesterol absorption inhibitors as a therapeutic option for hypercholesterolaemia

TL;DR: This review focuses on the recent progress in the molecular mechanisms of intestinal cholesterol absorption and transport, and novel therapeutic approaches to inhibit the cholesterol absorption process.
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Treatment of dyslipidemia: Genetic interactions with diet and drug therapy

TL;DR: Continuous progress in this area of research is getting us closer to the development of genetic screening panels that will allow a more precise assessment of individual CHD risk and response to therapeutic interventions.
References
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Serum total cholesterol and long-term coronary heart disease mortality in different cultures. Twenty-five-year follow-up of the seven countries study

TL;DR: The large difference in absolute CHD mortality rates at a given cholesterol level, however, indicates that other factors, such as diet, that are typical for cultures with a low CHD risk are also important with respect to primary prevention.
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Dietary fat and risk of coronary heart disease in men: cohort follow up study in the United States.

TL;DR: The data do not support the strong association between intake of saturated fat and risk of coronary heart disease suggested by international comparisons, but they are compatible with the hypotheses that saturatedfat and cholesterol intakes affect the risk of heart disease as predicted by their effects on blood cholesterol concentration.
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Intake of Fatty Acids and Risk of Coronary Heart Disease in a Cohort of Finnish Men: The Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study

TL;DR: A significant positive association was observed between the intake of trans-fatty acids and the risk of coronary death in a cohort of 21,930 smoking men aged 50-69 years who were initially free of diagnosed cardiovascular disease.
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Dietary fat and serum lipids: an evaluation of the experimental data.

TL;DR: Regression analysis of the combined published data on the effects of dietary fatty acids and cholesterol on serum cholesterol and lipoprotein cholesterol evaluated with groups of human subjects shows that saturated fatty acids increase and are the primary determinants of serum cholesterol.
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Diet and 20-year mortality from coronary heart disease. The Ireland-Boston Diet-Heart Study.

TL;DR: The hypothesis that diet is related, albeit weakly, to the development of coronary heart disease is supported.
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