Dietary protein restriction causes modification in aluminum-induced alteration in glutamate and GABA system of rat brain
TLDR
Modification of dietary protein level or manipulation of the brain amino acid homeostasis by any other means may be an useful tool to find out a path to restrict amino acid neurotransmitter alterations in aluminum-associated neurodisorders.Abstract:
Background
Alteration of glutamate and γ-aminobutyrate system have been reported to be associated with neurodegenerative disorders and have been postulated to be involved in aluminum-induced neurotoxicity as well. Aluminum, an well known and commonly exposed neurotoxin, was found to alter glutamate and γ-aminobutyrate levels as well as activities of associated enzymes with regional specificity. Protein malnutrition also reported to alter glutamate level and some of its metabolic enzymes. Thus the region-wise study of levels of brain glutamate and γ-aminobutyrate system in protein adequacy and inadequacy may be worthwhile to understand the mechanism of aluminum-induced neurotoxicity.read more
Citations
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References
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Book
The Biochemical Basis of Neuropharmacology
TL;DR: The fifth edition of the book as discussed by the authors contains two new chapters on topics of current interest: molecular neurobiology and neuromodulation, as well as all other chapters have been updated.
Journal ArticleDOI
Brain aluminum distribution in Alzheimer's disease and experimental neurofibrillary degeneration.
TL;DR: In this article, aluminum concentrations approaching those used experimentally have been found in some regions of the brains of patients with Alzheimer's disease, which is an important pathological finding in senile and presenile dementia of the Alzheimer type.