Journal ArticleDOI
Differing cardiotropic and myocarditic properties of group B type 4 coxsackievirus strains.
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TLDR
There may be various pathogenic or immunopathogenic mechanisms by which CBV-4 can produce myocarditis, and a murine model system for evaluation of myocarditic and cardiotropic properties of strains of group B, type 4 coxsackievirus was developed.Abstract:
A murine model system for evaluation of myocarditic and cardiotropic properties of strains of group B, type 4 coxsackievirus (CBV-4) was developed in male BALB/c mice 4 weeks of age Differing cardiotropic and myocarditic properties could be identified among field strains within the CBV-4 serotype These properties were consistent for the virus strains, and were independent of the infecting virus dose Virus replication in the heart appeared to be essential for development of myocarditis, but some infected hearts with high levels of infectious virus did not show myocarditis Two of the myocarditic strains showed different histopathology in infected hearts; with one strain (Mil) the myocarditis was characterized by a marked inflammatory reaction with occasional accompanying myofiber necrosis With the other strain (Bol), necrosis was the predominant finding, with a much lesser degree of inflammation These findings suggest that there may be various pathogenic or immunopathogenic mechanisms by which CBV-4 can produce myocarditisread more
Citations
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Journal ArticleDOI
Coxsackievirus myocarditis: interplay between virus and host in the pathogenesis of heart disease.
TL;DR: Recent work demonstrates that CVB evolves into a slowly replicating form capable of establishing a low-grade infection in the heart, and the innate immune response to CVB has taken on increasing importance.
Journal ArticleDOI
Derivation and characterization of an efficiently myocarditic reovirus variant.
TL;DR: Results from inoculations of athymic mice demonstrated that T cells were not a requirement for the 8B-induced myocarditis, and 8B was more cytopathic than either of the parent viruses in cultured mouse L cells, suggesting that reovirus thus provides a useful model for the study of viral myocardia.
Book ChapterDOI
Picornaviridae: The Enteroviruses (Polioviruses, Coxsackieviruses, Echoviruses)
TL;DR: Diseases: Minor illness (all types); aseptic meningitis, exanthema (many types); poliomy-elitis, polioencephalitis (some specific types); vesicular disease (some types); pleurodynia; (neonatal) carditis ( some types); acute hemorrhagic conjunctivitis (two types).
Journal ArticleDOI
Enteroviruses and Parechoviruses.
TL;DR: In transplant recipients and patients with malignancy, enterovirus infections typically involve the respiratory tract, but cases of severe, disseminated infection have been described, and routine nucleic acid-detection methods for enteroviral infections will not detect human parechoviruses.
Book ChapterDOI
Epidemiology of Group B Coxsackieviruses
TL;DR: Most of the conclusions concerning enteroviruses in general are directly applicable to CVB, including seasonality; geographic, age, and sex distribution; incidence and prevalence; transmission; and most clinical syndromes.
References
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Journal ArticleDOI
Age-Dependent Pathogenicity of Group B Coxsackieviruses in Swiss-Webster Mice: Infectivity for Myocardium and Pancreas
TL;DR: Specific susceptibilities to infection with coxsackieviruses group B vary with age of the mouse, virus type (and strain), and organ, whereas three- to five-month-old mice infected with coxsackievirus B1, B2, B3, or B4 showed maximal susceptibility to destructive lesions in the exocrine glandular pancreas.
Journal ArticleDOI
Heterogeneity of Coxsackie B4 virus: two kinds of particles which differ in antibody sensitivity, growth rate, and plaque size.
TL;DR: The presence of two kinds of particles in varying proportions in Coxsackie B4 virus strains provides an explanation for some of the problems encountered in previous immunological studies with these strains.
Journal ArticleDOI
Diversity within a human isolate of coxsackie B4: Relationship to viral‐induced diabetes
TL;DR: Observations suggest that the Edwards isolate of CB4, like other human isolates ofCB4 virus, probably exists as a heterogenous population of virion strains and the pathogenic consequences and expression of any diabetogenic potential is dependent on virus strain selection.
Journal ArticleDOI
Experimental Coxsackievirus Endocarditis
TL;DR: There is no basis for assuming that some instances of acute and chronic valvulitis in man may be viral in This opinion was based on the following considerations: a relatively large number of patients considered to have rheumatic valvular disease give no history of rhematic fever.