Journal ArticleDOI
Dissolution of Ketoprofen from Poly(Ethylene Glycol) Solid Dispersions
A. V. Belyatskaya,Ivan I. Krasnyuk,O. I. Stepanova,T. M. Kosheleva,T. P. Kudinova,A. N. Vorob’ev,M. M. Maryanyan +6 more
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TLDR
In this article, the effect of solid dispersions on the solubility of the nonsteroidal anti-inflammatory drug ketoprofen was determined, and the results could be used to develop rapidly dissolving keprofen solid dosage forms.Abstract:
The effect of solid dispersions (SDs) on the solubility of the nonsteroidal anti-inflammatory drug ketoprofen was determined. Ketoprofen and its SDs with poly(ethylene glycol) PEG-400, -1000, -1500, -2000, and -3000 were studied. Dissolution of ketoprofen from the SDs increased by 1.2 – 1.8 times; the dissolution rate, by 1.7 – 2.4 times. The improved release of ketoprofen from the SDs was proposed to be due to several factors such as solubilization and amorphization of the compound and formation of intermolecular H-bonds. The results could be used to develop rapidly dissolving ketoprofen solid dosage forms.read more
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Design of oral intestinal-specific alginate-vitexin nanoparticulate system to modulate blood glucose level of diabetic rats
TL;DR: The PEG compacted nanoparticles exhibited oral intestinal-specific vitexin release, with positive blood glucose lowering and enhanced intestinal viteXin content in vivo.
Journal ArticleDOI
Strategies for Solubility Enhancement of Anthelmintics (Review)
TL;DR: In this paper, the development and application of mechanochemical technology to modify sparingly soluble anthelmintic drugs is described, which consists essentially of joint mechanical treatment of a drug substance and polymer in grinder-activators of controlled energy.
Journal ArticleDOI
Solid Dispersions of Medamine and Albendazole with Water-Soluble Polymers: Preparation and Properties
TL;DR: In this paper, solid dispersions of medamine and albendazole with water-soluble polymers (PVP, arabinogalactan) were obtained by mechanochemical technology to increase the aqueous solubility of poorly soluble anthelmintic drug substances.
Journal ArticleDOI
Study of the Solubility of Furazolidone from Solid Dispersions with Polyvinylpyrrolidone
A. V. Beliatskaya,Ivan I. Krasnyuk,A. O. Elagina,I. M. Kashlikova,O. I. Stepanova,A. N. Vorob’yov,A. N. Kuzmenko,S. G. Iskenderova,D. R. Kannieva +8 more
TL;DR: In this article, the effect of solid dispersions on the solubility of furazolidone was studied and it was shown that the increase in solubile and dissolution rate of SDs is caused by the loss of crystallinity and the formation of a solid solution.
Journal ArticleDOI
Development of nitrofuran derivative: composition and technology of effervescent tablets with solid dispersions
A. O. Elagina,A. V. Belyatskaya,I. I. Krasnyuk (jr.),Ivan I. Krasnyuk,O. I. Stepanova,Tatyana V Fateeva,Elena A Smolyarchuk,S. V. Kozin,O. N. Plakhotnaya,O. V. Rаstopchina,Julietta V. Rau +10 more
TL;DR: In this paper , the authors developed the composition and technology for obtaining effervescent tablets based on solid dispersions of furazolidone in the form of an aqueous solution for external use.
References
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Journal ArticleDOI
Effect of Solid Dispersions on the Dissolution of Ampicillin
Ivan I. Krasnyuk,A. V. Beliatskaya,O. I. Stepanova,L. A. Korol,A. M. Valeeva,V. V. Grikh,L. V. Ovsyannikova,T. M. Kosheleva +7 more
TL;DR: In this article, the water solubility of ampicillin trihydrate and its solid dispersions with polyethylene glycol-1500, polyvinylpyrrolidone-10000, and β-cyclodextrin was studied.
Journal ArticleDOI
Solubility of Diclofenac Acid Form from Solid Dispersions
Ivan I. Krasnyuk,L. V. Ovsyannikova,O. I. Nikulina,A. V. Belyatskaya,Yu. Ya. Kharitonov,V. V. Grikh,L. A. Korol,Yu. A. Obidchenko,A. N. Vorob’ev +8 more
TL;DR: In this paper, the influence of solid dispersions (SD) on diclofenac solubility was determined by studying the acid form and its SD with polyethyleneglycol-1500 (PEG) and polyvinylpyrrolidone-10000 (PVP).
Drug synthesis methods and manufacturing technology solubility of diclofenac acid form from solid dispersions
Ivan I. Krasnyuk,L. V. Ovsyannikova,O. I. Nikulina,A. V. Belyatskaya,V. V. Grikh,L. A. Korol,A. N. Vorob +6 more
TL;DR: In this article, the influence of solid dispersions (SD) on diclofenac solubility was determined by studying the acid form and its SD with polyethyleneglycol-1500 (PEG) and polyvinylpyrrolidone-10000 (PVP).
Journal ArticleDOI
Studies of the Solubility of Rutin from Solid Dispersions
I. V. Koval’skii,Ivan I. Krasnyuk,O. I. Nikulina,A. V. Belyatskaya,Yu. Ya. Kharitonov,N.B. Feldman,Sergey V. Lutsenko,V. V. Grikh +7 more
TL;DR: The effects of solid dispersions (SD) on the solubility of rutin were studied in this article, and the physicochemical methods used in this paper suggested that improvements in release from SD result from decreases in crystallinity and formation of solid solutions of drug in polymer.