DNA fragmentation induced in macrophages by gliotoxin does not require protein synthesis and is preceded by raised inositol triphosphate levels.
TLDR
The results indicate that protein synthesis is not required for induction of apoptosis in macrophages or T blasts by gliotoxin, and the effects of actinomycin D and the protein synthesis inhibitor cycloheximide on apoptosis induced bygliotoxin are studied.About:
This article is published in Journal of Biological Chemistry.The article was published on 1990-08-25 and is currently open access. It has received 187 citations till now. The article focuses on the topics: Gliotoxin & Fragmentation (cell biology).read more
Citations
More filters
Journal ArticleDOI
Apoptosis. Its significance in cancer and cancer Therapy
TL;DR: C‐myc expression has been shown to be involved in the initiation of apoptosis in some situations, and bcl‐2 has emerged as a new type of proto‐oncogene that inhibits apoptosis, rather than stimulating mitosis.
Journal ArticleDOI
Aspergillus fumigatus and Aspergillosis
TL;DR: This review focuses on the biology of A. fumigatus, one of the most ubiquitous of the airborne saprophytic fungi, and the diseases it causes, and discusses discussions of genomic and molecular characterization of the organism.
Aspergillus fumigatus and aspergillosis.
TL;DR: A review of the biology of Aspergillus fumigatus and the diseases it causes can be found in this article, where the authors discuss genomic and molecular characterization of the organism, clinical and laboratory methods available for the diagnosis of aspergillosis in immunocompetent and immunOCompromised hosts, identification of host and fungal factors that play a role in the establishment of the fungus in vivo, and problems associated with antifungal therapy.
Journal Article
Specific Proteolytic Cleavage of Poly(ADP-ribose) Polymerase: An Early Marker of Chemotherapy-induced Apoptosis
TL;DR: The results suggest that proteolytic cleavage of pADPRp, in addition to being an early marker of chemotherapy-induced apoptosis, might reflect more widespread proteolysis that is a critical biochemical event early during the process of physiological cell death.
Journal ArticleDOI
Apoptosis: the biochemistry and molecular biology of programmed cell death.
TL;DR: This review first briefly covers some historical perspective on the discovery of apoptotic cell death, the characteristic morphology that accompanies this process, and the numerous cell types and mediators with which programmed cell death is associated.
References
More filters
Journal ArticleDOI
Glucocorticoid-induced thymocyte apoptosis is associated with endogenous endonuclease activation
TL;DR: It is shown here that this morphological change is closely associated with excision of nucleosome chains from nuclear chromatin, apparently through activation of an intracellular, but non-lysosomal, endonuclease.
Journal ArticleDOI
Inositol phosphates and cell signalling
TL;DR: The subtlety of calcium regulation by inositol phosphates is emphasized by recent studies that have revealed oscillations in calcium concentration which are perhaps part of a frequency-encoded second-messenger system.
Journal ArticleDOI
Chromatin cleavage in apoptosis: association with condensed chromatin morphology and dependence on macromolecular synthesis.
TL;DR: The data confirm that the condensed chromatin which characterizes apoptosis morphologically consists of endogenously digested chromatin fragments, and provide support for the view that at least some cells enter apoptosis by a process dependent upon macromolecular synthesis.
Journal Article
Glucocorticoid activation of a calcium-dependent endonuclease in thymocyte nuclei leads to cell death.
J. John Cohen,Richard C. Duke +1 more
TL;DR: It appears that glucocorticoids cause thymocyte death by activating an enzyme that rapidly and extensively degrades DNA, and it is suggested that it may be part of a system for transporting calcium into the nucleus.
Journal Article
Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes.
Karen S. Sellins,J. John Cohen +1 more
TL;DR: By studying the mechanism of DNA fragmentation induced during the interphase death of lymphocytes, this work hopes to understand better the extreme sensitivity of resting lymphocytes to radiation and what may be the common final pathway of programmed cell death.