Aspergillus fumigatus and Aspergillosis
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TLDR
This review focuses on the biology of A. fumigatus, one of the most ubiquitous of the airborne saprophytic fungi, and the diseases it causes, and discusses discussions of genomic and molecular characterization of the organism.Abstract:
Aspergillus fumigatus is one of the most ubiquitous of the airborne saprophytic fungi. Humans and animals constantly inhale numerous conidia of this fungus. The conidia are normally eliminated in the immunocompetent host by innate immune mechanisms, and aspergilloma and allergic bronchopulmonary aspergillosis, uncommon clinical syndromes, are the only infections observed in such hosts. Thus, A. fumigatus was considered for years to be a weak pathogen. With increases in the number of immunosuppressed patients, however, there has been a dramatic increase in severe and usually fatal invasive aspergillosis, now the most common mold infection worldwide. In this review, the focus is on the biology of A. fumigatus and the diseases it causes. Included are discussions of (i) genomic and molecular characterization of the organism, (ii) clinical and laboratory methods available for the diagnosis of aspergillosis in immunocompetent and immunocompromised hosts, (iii) identification of host and fungal factors that play a role in the establishment of the fungus in vivo, and (iv) problems associated with antifungal therapy.read more
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Genomic sequence of the pathogenic and allergenic filamentous fungus Aspergillus fumigatus
William C. Nierman,William C. Nierman,Arnab Pain,Michael J. Anderson,Jennifer R. Wortman,Jennifer R. Wortman,H. Stanley Kim,H. Stanley Kim,Javier Arroyo,Matthew Berriman,Keietsu Abe,David B. Archer,Clara Bermejo,Joan W. Bennett,Paul Bowyer,Dan Chen,Dan Chen,Matthew Collins,Richard Coulsen,Robert L. Davies,Paul S. Dyer,Mark L. Farman,Nadia Fedorova,Nadia Fedorova,Natalie D. Fedorova,Natalie D. Fedorova,T. Feldblyum,T. Feldblyum,Reinhard Fischer,Nigel Fosker,Audrey Fraser,José Luis García,María Josefa Marcos García,Ariette Goble,Gustavo H. Goldman,Katsuya Gomi,Sam Griffith-Jones,R. Gwilliam,Brian J. Haas,Brian J. Haas,Hubertus Haas,David Harris,H. Horiuchi,Jiaqi Huang,Jiaqi Huang,Sean Humphray,Javier Jiménez,Nancy P. Keller,H. Khouri,H. Khouri,Katsuhiko Kitamoto,Tetsuo Kobayashi,Sven Konzack,Resham Kulkarni,Resham Kulkarni,Toshitaka Kumagai,Anne Lafton,Jean-Paul Latgé,Weixi Li,Angela Lord,Charles Lu,Charles Lu,William H. Majoros,William H. Majoros,Gregory S. May,Bruce L. Miller,Yasmin Ali Mohamoud,Yasmin Ali Mohamoud,María Molina,Michel Monod,Isabelle Mouyna,Stephanie Mulligan,Stephanie Mulligan,Lee Murphy,Susan O'Neil,Ian T. Paulsen,Ian T. Paulsen,Miguel A. Peñalva,Mihaela Pertea,Mihaela Pertea,Claire Price,Bethan L. Pritchard,Michael A. Quail,Ester Rabbinowitsch,Neil Rawlins,Marie Adele Rajandream,Utz Reichard,Hubert Renauld,Geoffrey D. Robson,Santiago Rodríguez de Córdoba,José Manuel Rodríguez-Peña,Catherine M. Ronning,Catherine M. Ronning,Simon Rutter,Steven L. Salzberg,Steven L. Salzberg,Miguel del Nogal Sánchez,Juan C. Sánchez-Ferrero,David L. Saunders,Kathy Seeger,Rob Squares,S. Squares,Michio Takeuchi,Fredj Tekaia,Geoffrey Turner,Carlos R. Vázquez de Aldana,J. Weidman,J. Weidman,Owen White,Owen White,John Woodward,Jae-Hyuk Yu,Claire M. Fraser,Claire M. Fraser,James E. Galagan,Kiyoshi Asai,Masayuki Machida,Neil Hall,Neil Hall,Bart Barrell,David W. Denning +120 more
TL;DR: The Af293 genome sequence provides an unparalleled resource for the future understanding of this remarkable fungus and revealed temperature-dependent expression of distinct sets of genes, as well as 700 A. fumigatus genes not present or significantly diverged in the closely related sexual species Neosartorya fischeri, many of which may have roles in the pathogenicity phenotype.
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Guidelines for environmental infection control in health-care facilities. Recommendations of CDC and the Healthcare Infection Control Practices Advisory Committee (HICPAC).
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Invasive aspergillosis in allogeneic stem cell transplant recipients: changes in epidemiology and risk factors
TL;DR: Risk factor analyses verify previously recognized risk factors (GVHD, receipt of corticosteroids, and neutropenia) and uncover the roles of lymphopenia and viral infections in increasing the incidence of postengraftment IA in the 1990s.
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Pathogenesis of Aspergillus fumigatus in Invasive Aspergillosis
TL;DR: An overview of the significant findings regarding A. fumigatus pathogenesis as it pertains to invasive disease is provided.
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