Journal ArticleDOI
Doxycycline Reduces Early Neurologic Impairment after Cerebral Arterial Air Embolism in the Rabbit
Daniel K. Reasoner,Bradley J. Hindman,Franklin Dexter,Alberto Subieta,Johann Cutkomp,Tom Smith +5 more
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TLDR
Doxycycline decreased electrophysiologic and neurologic abnormalities after cerebral air embolism and appears to inhibit a key early process in the pathophysiology of cerebral air Embolism.Abstract:
Background Previous studies indicate leukocytes play a role in the pathogenesis of cerebral arterial air embolism. Because doxycycline inhibits numerous leukocyte activities, the authors hypothesized doxycycline would decrease neurologic impairment after cerebral arterial air embolism. Methods New Zealand White rabbits anesthetized with methohexital received either intravenous saline (n = 7) or 10 mg/kg doxycycline (n = 7) 1 h before administration of 100 micro liter/kg of air into the internal carotid artery. Somatosensory-evoked potentials (SSEPs) were recorded at 30-min intervals for the next 2 h. After the final recording, the anesthetic was discontinued, and animals recovered. Animals were neurologically evaluated 4 h after air embolism on a scale of 0 (normal) to 99 (coma) points. Results At 4 h, doxycycline animals had lesser neurologic impairment (46 +/- 23; median, 41) than animals that received saline (77 +/- 20; median, 81); P = 0.007. SSEP amplitude was greater in the doxycycline group at 60, 90, and 120 min after air embolism; P = 0.001, 0.006, 0.026, respectively. SSEP amplitudes at 30, 60, 90, and 120 min inversely correlated with 4 h neurologic impairment; tau = -0.43, -0.75, -0.85, -0.79, respectively. Conclusions Doxycycline decreased electrophysiologic and neurologic abnormalities after cerebral air embolism. Because groups could be distinguished electrophysiologically as soon as 1 h after air embolism and because SSEP amplitude inversely correlated with neurologic impairment, doxycycline appears to inhibit a key early ([approximately] 1 h) process in the pathophysiology of cerebral air embolism.read more
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Journal ArticleDOI
Doxycycline Suppresses Microglial Activation by Inhibiting the p38 MAPK and NF-kB Signaling Pathways
Flávia Viana Santa-Cecília,Benjamin Socias,Mohand Ouidir Ouidja,Julia E. Sepulveda-Diaz,Leonardo Acuña,Rangel L. Silva,Patrick P. Michel,Elaine Del-Bel,Thiago M. Cunha,Rita Raisman-Vozari +9 more
TL;DR: The present results indicate that the effect of doxycycline on LPS-induced microglial activation probably occurs via the modulation of p38 MAP kinase and NF-kB signaling pathways, and support the idea that doxy cycline may be useful in preventing or slowing the progression of PD and other neurodegenerative diseases that exhibit altered glia function.
Journal ArticleDOI
Cortical blindness and neurologic injury complicating cervical transforaminal injection for cervical radiculopathy.
Journal ArticleDOI
Regional patterns of neuronal death after deep hypothermic circulatory arrest in newborn pigs
TL;DR: In neonates, neocortical and hippocampal neurons are selectively vulnerable to death after DHCA, suggesting the need for several neuroprotective strategies tailored to the region and death process, initiated during the operation and continued after the operation.
BookDOI
Tetracyclines in biology, chemistry, and medicine
TL;DR: Tetracyclines and CMTs modulate anti-inflammatory mediators such as IL-lO (mRNA level) and type II IL- l ~ decoy receptor (secretory enzyme level), which make them candidate drugs for complex multifactoral inflammatory diseases.
Journal ArticleDOI
Brain injury after adult cardiac surgery.
Jouni Ahonen,Markku Salmenperä +1 more
TL;DR: The incidence of brain injury may be reduced by modifying the surgical procedure according to carotid duplex scanning and epiaortic echocardiography, by using techniques to reduce microembolization during cardiopulmonary bypass and by optimizing patient temperature during and after surgery.
References
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