Drug abuse in schizophrenic patients: clinical correlates and reasons for use.
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TLDR
Schizophrenic patients who abuse drugs may represent a subgroup of patients with better prognoses and less severe clinical characteristics of schizophrenia, but their drug abuse may adversely affect global outcome.Abstract:
Objective: This study aimed to 1) determine substance abuse prevalence and preference in a diverse sample ofschizophrenic, schizoaffective, and schizophreniform inpatients, 2) cornpare drug-abusing and non-drug-abusing patients on demographic and clinical variables during the acute and stabilization phases of their hospital course, and 3) obtain data from patients on reasons for drug abuse and on acute state-related changes during periods of intoxication. Method: Eighty-three psychotic inpatients consecutively admitted to a New York City teaching hospital were evaluated. Sixty-eight had schizophrenia, 12 had schizoaffective disorder, and three had schizophreniforrn disorder diagnosed according to the Structured Clinical Interview for DSM-III-R. Each patient received ratings on the Brief Psychiatric Rating Scale, the Global Assessment Scale, and the Scale for the Assessment of Negative Symptoms at admission and at discharge, an evaluation of premorbid adjustment, and an extensive interview on drug and alcohol use. Results: Forty (48%) of the patients received diagnoses of drug or alcohol abuse or dependence. The drug-abusing patients primanly used cannabis (N=26), alcohol (N=2 1), and cocaine (N= I 4) and reported that they abused drugs to get “high, “ to relieve depression, and to relax. They had significantly fewer positive and negative symptoms at discharge, better sexual adjustment and worse school performance during adolescence, and more family histories ofdrug abuse than the non-d rugabusing patients. Conclusions: Schizophrenic patients who abuse drugs may represent a subgroup of patients with better prognoses and less severe clinical characteristics of schizophrenia, but their drug abuse may adversely affect global outcome.read more
Citations
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MAM (E17) rodent developmental model of neuropsychiatric disease: disruptions in learning and dysregulation of nucleus accumbens dopamine release, but spared executive function.
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The Longitudinal Impact of Intrinsic Motivation on Substance Use Severity in Schizophrenia and its Patterns in Men and Women
TL;DR: Evidence was found suggesting longitudinal intrinsic motivation change is a salient incremental predictor of reductions in patient’s alcohol/ drug use severity, above and beyond the effects of age, illness chronicity, overall psychopathology, comorbidity status, and phase 1 randomization medication effects.
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Poids de la comorbidité addictive dans le risque d’observance partielle au traitement médicamenteux et de rechute dans la schizophrénie
A. Ameller,P. Gorwood,P. Gorwood +2 more
TL;DR: La comorbidite addictive a un poids significatif (p Conclusion Le poids des addictions comorbides represente entre 1/5 et 1/3 des facteurs en jeu dans l’observance and le risque de rechute des patients souffrant de schizophrenie.
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Drugs and Psychosis Project: a multi-centre European study on comorbidity.
Alex Baldacchino,Hannah Blair,Norbert Scherbaum,Eva Grosse-Vehne,Marco Riglietta,L. Tidone,Caterina Criaco,Maria C. Marelli,Borge Sommer,Liz Tan,Hilary J. Little,Hamid Ghodse +11 more
TL;DR: Cross-cultural differences in the sociodemographic characteristics of the comorbid patient population give a better insight into this heterogenous group of psychotic patients.
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Psychosis and substance abuse: cause, effect or coincidence?
Stephen M. Lawrie,J. K. Hutchison,S. R. Sweeney,M. R. Fernando,C. A. McAdam,M. R. Monsour,T. J. Campbell,C. M. Macleod +7 more
TL;DR: In this article, a survey of 38 consecutively admitted patients with DSM-III-R functional psychoses was conducted and a semi-structured substance abuse interview was administered and a urine specimen for drug metabolite screening requested.
References
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John E. Overall,Donald R. Gorham +1 more
TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
Journal ArticleDOI
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Darrel A. Regier,Jeff Boyd,Jack D. Burke,Donald S. Rae,Jerome K. Myers,Morton Kramer,Lee N. Robins,Linda K. George,Marvin Karno,Ben Z. Locke +9 more
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Journal ArticleDOI
Measurement of Premorbid Adjustment in Chronic Schizophrenia
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