Drug abuse in schizophrenic patients: clinical correlates and reasons for use.
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TLDR
Schizophrenic patients who abuse drugs may represent a subgroup of patients with better prognoses and less severe clinical characteristics of schizophrenia, but their drug abuse may adversely affect global outcome.Abstract:
Objective: This study aimed to 1) determine substance abuse prevalence and preference in a diverse sample ofschizophrenic, schizoaffective, and schizophreniform inpatients, 2) cornpare drug-abusing and non-drug-abusing patients on demographic and clinical variables during the acute and stabilization phases of their hospital course, and 3) obtain data from patients on reasons for drug abuse and on acute state-related changes during periods of intoxication. Method: Eighty-three psychotic inpatients consecutively admitted to a New York City teaching hospital were evaluated. Sixty-eight had schizophrenia, 12 had schizoaffective disorder, and three had schizophreniforrn disorder diagnosed according to the Structured Clinical Interview for DSM-III-R. Each patient received ratings on the Brief Psychiatric Rating Scale, the Global Assessment Scale, and the Scale for the Assessment of Negative Symptoms at admission and at discharge, an evaluation of premorbid adjustment, and an extensive interview on drug and alcohol use. Results: Forty (48%) of the patients received diagnoses of drug or alcohol abuse or dependence. The drug-abusing patients primanly used cannabis (N=26), alcohol (N=2 1), and cocaine (N= I 4) and reported that they abused drugs to get “high, “ to relieve depression, and to relax. They had significantly fewer positive and negative symptoms at discharge, better sexual adjustment and worse school performance during adolescence, and more family histories ofdrug abuse than the non-d rugabusing patients. Conclusions: Schizophrenic patients who abuse drugs may represent a subgroup of patients with better prognoses and less severe clinical characteristics of schizophrenia, but their drug abuse may adversely affect global outcome.read more
Citations
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Cannabis and acute psychosis
Philip McGuire,Peter B. Jones,I. Harvey,Paul Bebbington,Brian Toone,Shôn Lewis,Robin M. Murray +6 more
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Adverse pregnancy outcome in schizophrenic women: occurrence and risk factors.
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The spectrum of substance abuse in bipolar disorder: reasons for use, sensation seeking and substance sensitivity
Jacopo V. Bizzarri,Alfredo Sbrana,Paola Rucci,Paola Rucci,Laura Ravani,Guido Jacopo Massei,Chiara Gonnelli,S. Spagnolli,M. R. Doria,Federica Raimondi,Jean Endicott,Liliana Dell'Osso,Giovanni B. Cassano +12 more
TL;DR: Recourse to substances is associated with increased mood and anxiety symptoms, substance sensitivity, and sensation seeking among patients with BPD + SUD and SUD.
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A randomized controlled pilot study of motivational interviewing for patients with psychotic and drug use disorders.
TL;DR: The findings indicate that MI may not work equally well for all types of psychotic disordered dually diagnosed patients and that alternative approaches may be as effective in fostering improved substance use treatment outcomes for subgroups of these individuals.
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Response inhibition and cognitive flexibility in schizophrenia with and without comorbid substance use disorder.
TL;DR: Dual diagnosis patients did not differ significantly from non-addicted schizophrenia patients or from the alcoholic group, but were impaired at cognitive flexibility relative to the depression subgroup and healthy controls, contrary to expectation.
References
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TL;DR: The Brief Psychiatric Rating Scale (BRS) as mentioned in this paper was developed to provide a rapid assessment technique particularly suited to the evaluation of patient change, and it is recommended for use where efficiency, speed, and economy are important considerations.
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Journal ArticleDOI
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