Effect of endotoxin on tumor resistance in mice.
Cynara Yang,Alois Nowotny +1 more
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It appears that a 10-mug dose of ET was approximately the optimal dose for protection; pretreatment with ET 3 to 0 days prior to tumor challenge gave best protection; and the intravenous injection of ET showed a lower protection against the tumor than intraperitoneal application.Abstract:
As reported earlier, an intraperitoneal injection of 1 μg of endotoxin (ET) from Serratia marcescens rendered mice resistant against the nonspecific mouse ascites tumor TA3-Ha upon challenge 24 h after pretreatment with ET. Further studies were aimed at the elaboration of conditions which achieved maximal resistance. It appears that (i) a 10-μg dose of ET was approximately the optimal dose for protection; (ii) pretreatment with ET 3 to 0 days prior to tumor challenge gave best protection; and (iii) the intravenous injection of ET showed a lower protection against the tumor than intraperitoneal application. Studies on the mechanism of ET protection indicate that (i) ET does not have a direct cytotoxic effect on tumor cells; (ii) normal spleen cells exposed to ET in vitro can adoptively transfer protection against tumor; and (iii) spleen cells activated in vivo by intravenous injection of ET can adoptively transfer protection. The possible involvement of mononuclear cells is discussed.read more
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Book ChapterDOI
Bacterial endotoxins and host immune responses
David C. Morrison,John L. Ryan +1 more
TL;DR: This chapter discusses the nature of endotoxins and their interactions with cells of the immune system, leading to direct interaction of endotoxin with B lymphocytes leading to the formation of antibodies to endotoxin as well as a spectrum of other immunoglobulin molecules.
Journal ArticleDOI
Immunocompetent cells in resistance to bacterial infections.
TL;DR: The Immunity of Bone Marrow-Derived Cells in Cell-Mediated Immunity and the Role of B Cells in Humoral Antibody Production is illustrated.
Journal ArticleDOI
Relation of structure to function in bacterial O-antigens—VII. Endotoxicity of ‘lipid A’
Chung-Ming Chang,Alois Nowotny +1 more
TL;DR: The more limited use of the term ‘lipid A’ and more accurate description of the various lipid-rich endotoxin derivatives is recommended, as Biological activities and molecular ratios of this subtance reveal some similarities between endotoxic glycolipids and this material.
Journal ArticleDOI
Increased resistance and depressed delayed-type hypersensitivity to Listeria monocytogenes induced by pretreatment with lipopolysaccharide.
TL;DR: The view that lipopolysaccharide stimulates a highly effective anti-Listeria immunity via the macrophage component, despite interference with the lymphocyte component is supported.
Journal ArticleDOI
Relationship of structure to function in bacterial endotoxins. IX. Differences in the lipid moiety of endotoxic glycolipids.
TL;DR: Not only the polysaccharide but the lipid moiety as well may vary in various gram-negative endotoxin preparations, which is claimed to be quite dissimilar in their biological effects.
References
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Journal ArticleDOI
Endotoxin and double stranded RNA render macrophages cytotoxic.
P. Alexander,R. Evans +1 more
TL;DR: The cytotoxicities of double stranded RNA and endotoxin have striking similarities and both seem to render mouse macrophages cytotoxicity to other mouse cells.
Journal ArticleDOI
Lymphocyte mediated cytotoxicity in vitro. Induction and inhibition by humoral antibody and nature of effector cells.
TL;DR: During the past decade, experimental evidence has been brought forward in many laboratories that lymphocytes are capable of destroying appropriate target cells in vitro and that humoral antibodies may induce cytotoxicity of thymus-independent lymphoid cells.
Journal Article
Stimulation of B-Lymphocytes by Endotoxin Reactions of Thymus-Deprived Mice and Karyotypic Analysis of Dividing Cells in Mice Bearing T6T6 Thymus Grafts
I. Gery,J. Krüger,S. Z. Spiesel +2 more
TL;DR: Thymus-independent B lymphocytes were shown to play the main role in the transformation response of mouse spleen cultures to endotoxin (LPS), while the responses to phytohemagglutinin and ConA were markedly depressed.
Journal ArticleDOI
Mitogens as probes for immunocyte activation and cellular cooperation.
TL;DR: A model for mitogen-induced lymphocyte stimulation and evidence for a soluble T cell factor are presented.
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