Effect of Erythrina velutina and Erythrina mulungu in rats submitted to animal models of anxiety and depression
TLDR
It is suggested that EV exerts anxiolytic-like effects on a specific subset of defensive behaviors which have been associated with generalized anxiety disorder, in contrast to the reference drug imipramine that significantly decreased immobility time after chronic treatment.Abstract:
Erythrina velutina (EV) and Erythrina mulungu (EM), popularly used in Brazil as tranquilizing agents, were studied. The effects of acute and chronic oral treatment with a water:alcohol extract of EV (7:3, plant grounded stem bark; acute = 100, 200, 400 mg/kg; chronic = 50, 100, 200 mg/kg) were evaluated in rats (N = 11-12) submitted to the elevated T-maze (for avoidance and escape measurements) model of anxiety. This model was selected for its presumed capacity to elicit specific subtypes of anxiety disorders recognized in clinical practice: avoidance has been related to generalized anxiety and escape to panic. Additionally, animals were treated with the same doses of EV and EM (water:alcohol 7:3, inflorescence extract) and submitted to the forced swim test for the evaluation of antidepressant activity (N = 7-10). Both treatment regimens with EV impaired elevated T-maze avoidance latencies, without altering escape, in a way similar to the reference drug diazepam (avoidance 1, mean ± SEM, acute study: 131.1 ± 45.5 (control), 9.0 ± 3.3 (diazepam), 12.7 ± 2.9 (200 mg/kg), 28.8 ± 15.3 (400 mg/kg); chronic study: 131.7 ± 46.9 (control), 35.8 ± 29.7 (diazepam), 24.4 ± 10.4 (50 mg/kg), 29.7 ± 11.5 (200 mg/kg)). Neither EV nor EM altered measurements performed in the forced swim test, in contrast to the reference drug imipramine that significantly decreased immobility time after chronic treatment. These results were not due to motor alterations since no significant effects were detected in an open field. These observations suggest that EV exerts anxiolytic-like effects on a specific subset of defensive behaviors which have been associated with generalized anxiety disorder.read more
Citations
More filters
Journal ArticleDOI
Medicinal plants of the caatinga (semi-arid) vegetation of NE Brazil: a quantitative approach.
Ulysses Paulino Albuquerque,Patrícia Muniz de Medeiros,Alyson Luiz Santos de Almeida,Júlio Marcelino Monteiro,Ernani Machado de Freitas Lins Neto,Joabe Gomes de Melo,Janaina Patrícia dos Santos +6 more
TL;DR: A survey of published information on the phytochemical and pharmacological status of the plants demonstrating the highest RI supported the veracity of their attributed folk uses.
Journal ArticleDOI
Erythrina mulungu alkaloids are potent inhibitors of neuronal nicotinic receptor currents in mammalian cells.
Pedro Setti-Perdigão,Maria A. R. Serrano,Otavio Flausino,Vanderlan da Silva Bolzani,Marília Zaluar P. Guimarães,Newton G. Castro +5 more
TL;DR: The data suggest that these Erythrina alkaloids may exert their behavioral effects through inhibition of CNS nicotinic acetylcholine receptors, particularly the α4β2 subtype.
Journal ArticleDOI
Serotonin in anxiety and panic: contributions of the elevated T-maze.
TL;DR: The elevated T-maze results point to the possible benefits of adjunctive opioid therapy for panic patients resistant to antidepressants that act on 5-HT neurotransmission.
Journal ArticleDOI
Plantas medicinais e seus constituintes bioativos: uma revisão da bioatividade e potenciais benefícios nos distúrbios da ansiedade em modelos animais
Francisca Cléa Florenço de Sousa,Carla Thiciane Vasconcelos de Melo,Maria do Carmo de Oliveira Citó,Francisca Helvira Cavalcante Félix,Silvânia Maria Mendes Vasconcelos,Marta Maria de França Fonteles,José Maria Barbosa Filho,Glauce Socorro de Barros Viana +7 more
TL;DR: O intuito desta revisao e fornecer uma ampla visao das plantas medicinais que apresentam efeitos terapeuticos significantes em modelos animais de doencas psiquiatricas, especificamente os disturbios da ansiedade será uma maior atencao em estudos posteriores.
References
More filters
Journal Article
Behavioral despair in mice: a primary screening test for antidepressants
Porsolt Rd,Bertin A,Jalfre M +2 more
TL;DR: The mouse procedure is more rapid and less costly than that with rats and is thus more suitable for the primary screening of antidepressant drugs, suggesting that the procedure is selectively sensitive to antidepressant treatments.
Journal ArticleDOI
The elevated T-maze: a new animal model of anxiety and memory.
TL;DR: Inhibitory avoidance remained impaired 3 days later in the rats treated with 1-4 mg/kg DZP, indicating anterograde amnesia, and dose-response curves were determined for the benzodiazepine anxiolytic and amnestic agent diazepam (DZP), as well as for ipsapirone (IPS, 0.25-2mg/kg).
Journal ArticleDOI
Behavioral effects of acute and chronic imipramine in the elevated T-maze model of anxiety.
TL;DR: The obtained results are compatible with the view that inhibitory avoidance and one-way escape in the elevated T-maze reflect different types of fear/anxiety, that may be related to generalized anxiety and panic disorder, respectively.
Journal Article
The elevated T maze, a new experimental model of anxiety and memory: effect of diazepam.
TL;DR: The view that the anxiolytic and amnestic effects of benzodiazepines are closely related is supported, and this new elevated T maze model may be useful for simultaneous measurement of drug effects on anxiety and memory is suggested.
Journal ArticleDOI
Isolation and characterization of new anti-HIV and cytotoxic leads from plants, marine, and microbial organisms.
Tawnya C. McKee,Heidi R. Bokesch,Jinping L. McCormick,Mohammad A. Rashid,Spielvogel D,Kirk R. Gustafson,Alavanja Mm,Cardelline Jh nd,Michael R. Boyd +8 more
TL;DR: New cytotoxic isomalabaricane triterpenes have been isolated from a sponge Stelletta sp.
Related Papers (5)
Antinociceptive activities of the hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu in mice.
Anticonvulsant activity of hydroalcoholic extracts from Erythrina velutina and Erythrina mulungu.
Silvânia Maria Mendes Vasconcelos,Natália Martins Lima,Gabriel T. M. Sales,Geanne M. A. Cunha,Lissiana Magna Vasconcelos Aguiar,Edilderto R. Silveira,Alexandre César Praxedes Rodrigues,Daniele S. Macedo,Marta Maria de França Fonteles,Francisca Cléa Florenço de Sousa,Glauce Socorro de Barros Viana +10 more